Background: To examine the association between a mindfulness-based stress reduction (MBSR) nursing model and changes in quality of life in patients with chronic tonsillitis complicated by anxiety disorder. Methods: This retrospective study analyzed propensity score-matched data from 110 patients (55 per group) with chronic tonsillitis and comorbid anxiety disorder treated at Yingshang County...
This randomized, double-blind, parallel-group trial evaluated the efficacy of a single intravenous dose of esketamine (0.3mg/kg) administered at anesthesia induction in reducing postoperative depression and anxiety among patients undergoing cardiac valve surgery. A total of 142 patients from three centers were randomly assigned to receive esketamine or saline. The primary outcomes were the...
The 5-hydroxytryptamine 2A receptor (5-HT2AR) is one of the key targets in the development of novel antidepressants. To develop new antidepressants targeting the 5-HT2A receptor, this study established a high-throughput screening method for drugs targeting the 5-HT2A receptor based on the principle of detecting calcium flux signals. The immunofluorescence assay and western blotting were...