Following publication of this article, the title has been updated to clarify that the study was observational rather than interventional, with text added in the Results and Methods to specify which analyses were pre-registered. The competing interests statement has also been updated to clarify the competing interests of Joe Dispenza and state those of Hemal H. Patel. The changes are made in the...
Abstract Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an...
Meditation has long been known to promote health. We utilized a multidisciplinary approach to investigate the impact of mind-body interventions on the body in a twin cohort during a week-long meditation retreat. This study was designed to address individual changes controlling for intersubject trait variation and explore the role of genetic background on multi-omic factors during meditation....
Our culture and its scientific endeavor direly need a holistic characterization of mind and body. Many phenomena attest to the profound effects of beliefs on bodily function (e.g., open-label placebo's effects on chronic pain) and interoceptive systems' role in mental processes (e.g., the emerging role of gut microbiomes in the mood). We need a mechanistic, integrative framework to account for...
This review examines recent (2016 onwards) neuroscientific findings on the mechanisms supporting mindfulness-associated pain relief. To date, its clear that mindfulness lowers pain by engaging brain processes that are distinct from placebo and vary across meditative training level. Due to rapid developments in the field of contemplative neuroscience, an update review on the neuroimaging studies...
Psychedelics, contemplative practice, and fasting are physiologically unrelated interventions that nevertheless converge, across cultures and centuries, on a common experiential endpoint: the mystical state. Here I propose that this convergence reflects shared disruption of a single computational architecture, the precision-weighted predictive hierarchy, through three mechanistically distinct...