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Krishnan Chakravarthy

2 papers in the library · 9 citations · publishing 2024-2026

Papers

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Brain mechanisms supporting mindfulness-based chronic pain relief: A randomized, sham-mindfulness meditation controlled mechanistic clinical trial protocol.

Contemporary Clinical Trials Communications June 27, 2026 Jon G Dean, Alessandro Allen, Daniel Barrows et al.

Introduction: Chronic low back pain (cLBP) is a leading cause of disability worldwide and is frequently refractory to pharmacological treatment. Mindfulness meditation has been shown to reduce pain through modulation of self-referential, cognitive and affective mechanisms. However, the neural mechanisms supporting the direct and immediate modulation of movement-evoked cLBP by mindfulness...

The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial.

Neuropsychopharmacology June 1, 2024 Lora Khatib, Jon G Dean, Valeria Oliva et al. 9 citations

Chronic low back pain (cLBP) is the most prevalent chronic pain condition. There are no treatments that haven been found to directly assuage evoked cLBP. To this extent, mindfulness-meditation is a promising pain therapy. Yet, it is unclear if meditation can be utilized to directly attenuate evoked chronic pain through endogenous opioids. A double-blind, randomized, and placebo-controlled...