Abstract Dysfunction in default mode network (DMN) connectivity plays a role in the etiology and maintenance of insomnia symptoms. Negative self-referential thinking is a perpetuating factor of insomnia that has been linked with DMN connectivity. The Bed Nucleus of the Stria Terminalis (BNST), part of the extended-amygdala pathway, facilitates cognitive and physiological hyperarousal. We...
SleepApril 20, 2024David Negelspach, Anna Alkozei, Alisa Huskey et al.
Abstract: Introduction: Decoupling patterns of sleep and wake from underlying circadian oscillations is associated with poor sleep health. While this has been studied with respect to shift work, it is unclear if minor variations in normative sleep/wake patterns affect the restoration of cognitive function during sleep intervals while controlling for total sleep time. It is commonplace to adhere...
Background Cortical hyperarousal and ruminative thinking are common aspects of insomnia that have been linked with greater connectivity in the default mode network (DMN). Therefore, disrupting network activity within the DMN may reduce cortical and cognitive hyperarousal and facilitate better sleep. Objective This trial aims to establish a novel, noninvasive method for treating insomnia through...
Insomnia is often accompanied by excessive pre-sleep rumination. Such ruminative thinking is also associated with increased connectivity of the default mode network (DMN). It is likely that DMN connectivity and associated rumination contribute to the pathogenesis of insomnia. We hypothesized that resting state functional connectivity (rsFC) between the DMN and other brain regions prior to...