SLEEP Advances
October 21, 2026
Alisa Huskey, Jungwon Cha, Lindsey L Hildebrand et al.
Abstract Dysfunction in default mode network (DMN) connectivity plays a role in the etiology and maintenance of insomnia symptoms. Negative self-referential thinking is a perpetuating factor of insomnia that has been linked with DMN connectivity. The Bed Nucleus of the Stria Terminalis (BNST), part of the extended-amygdala pathway, facilitates cognitive and physiological hyperarousal. We...
JMIR Research Protocols
January 26, 2024
Lindsey L Hildebrand, Alisa Huskey, Natalie S Dailey et al.
Background Cortical hyperarousal and ruminative thinking are common aspects of insomnia that have been linked with greater connectivity in the default mode network (DMN). Therefore, disrupting network activity within the DMN may reduce cortical and cognitive hyperarousal and facilitate better sleep. Objective This trial aims to establish a novel, noninvasive method for treating insomnia through...
Neuroreport
October 4, 2023
William D. S. Killgore, Samantha Jankowski, Kymberly Henderson-Arredondo et al.
19 citations
Insomnia is often accompanied by excessive pre-sleep rumination. Such ruminative thinking is also associated with increased connectivity of the default mode network (DMN). It is likely that DMN connectivity and associated rumination contribute to the pathogenesis of insomnia. We hypothesized that resting state functional connectivity (rsFC) between the DMN and other brain regions prior to...
Journal of Psychopharmacology
January 12, 2023
Anahita Bassir Nia, C. Gibson, Sharron A Spriggs et al.
Background: Cannabis use suppresses the endocannabinoid system in healthy individuals. However, the association between cannabis use with the endocannabinoid system is understudied in individuals with psychosis despite the high rate of cannabis use in these individuals. Methods: We enrolled 83 individuals who were admitted to an inpatient psychiatric unit with psychotic presentations, and...
Early Intervention in Psychiatry
May 16, 2021
L. Marino, Samantha Jankowski, R. Kent et al.
Cannabis use is common among individuals with first episode psychosis (FEP) and persistent use is associated with worse outcomes. The purpose of this qualitative study is to identify factors pertaining to onset of cannabis use and persistent use among young adults with early psychosis receiving coordinated specialty care (CSC) in the United States and begin to develop a theoretical framework to...