Abstract Dysfunction in default mode network (DMN) connectivity plays a role in the etiology and maintenance of insomnia symptoms. Negative self-referential thinking is a perpetuating factor of insomnia that has been linked with DMN connectivity. The Bed Nucleus of the Stria Terminalis (BNST), part of the extended-amygdala pathway, facilitates cognitive and physiological hyperarousal. We...
Background Cortical hyperarousal and ruminative thinking are common aspects of insomnia that have been linked with greater connectivity in the default mode network (DMN). Therefore, disrupting network activity within the DMN may reduce cortical and cognitive hyperarousal and facilitate better sleep. Objective This trial aims to establish a novel, noninvasive method for treating insomnia through...
Insomnia is often accompanied by excessive pre-sleep rumination. Such ruminative thinking is also associated with increased connectivity of the default mode network (DMN). It is likely that DMN connectivity and associated rumination contribute to the pathogenesis of insomnia. We hypothesized that resting state functional connectivity (rsFC) between the DMN and other brain regions prior to...