Objective: To explore the mechanism of trait mindfulness's influence on college students' rumination and to analyze the chain mediating role of exercise behavior and optimistic intelligence quotient. Methods: A questionnaire survey was conducted on 1983 Chinese university students (mean age of subjects 19.10 ± 1.07 years) using the Trait mindfulness Scale, the Rumination Scale, the Physical...
Childhood trauma has been found to be associated with suicidal ideation among youth. However, the underlying processes that link childhood trauma and suicidal ideation are unclear. This study investigates the role of nightmare frequency in the association between childhood trauma and suicidal ideation, and the potential moderating effect of sex. Youths were recruited from Fujian Province,...
Parents of children with cancer may experience persistent psychological distress and impaired physical health throughout their children's diagnosis and treatment. This study aimed to develop a mindful self-compassion program for parents of children with cancer and explore its effect. This pre-post-test study without a control group was conducted with 34 Chinese parents of children with cancer,...
The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks, including fatalities. Many SCRAs exhibit much higher efficacy and potency compared with the phytocannabinoid Δ 9 -tetrahydrocannabinol (THC) at the cannabinoid receptor 1 (CB1R), leading to dramatic differences in signaling levels that can be toxic. In...
The nonmedical (i.e., recreational) misuse of synthetic cannabinoids (SCs) is a worldwide public health problem. When compared to cannabis, the misuse of SCs is associated with a higher incidence of serious adverse effects, suggesting the possible involvement of noncannabinoid sites of action. Here, we find that, unlike the phytocannabinoid Δ9-tetrahydrocannabinol, the indole-moiety containing...
Seven new iboga-type alkaloids, ervaoffines A-D (1-4), (7S)-3-oxoibogaine hydroxyindolenine (5), ibogaine-5,6-dione (6), and 19-epi-5-oxovoacristine (7), and 10 known alkaloids were isolated from Ervatamia officinalis. The absolute configurations of 1-7 were determined through X-ray diffraction and electronic circular dichroism (ECD) analyses. Ervaoffines A and B represent the first iboga-type...
Sanwang Wang, Xiaobo Liu, Jinzhi He et al.
preprint
The default mode network (DMN) critically underpins cognitive and affective functions throughout the adult lifespan; however, detailed insights into its complex neuroarchitecture and connectivity patterns across aging remain limited. Leveraging the open-access CamCAN dataset, comprising structural and diffusion magnetic resonance imaging (MRI) alongside magnetoencephalography (MEG) data from...