Journal of molecular graphics & modelling
January 2024
Krishna Chaturvedi, Caroline S Anthony, Pankaj Pandey et al.
Synthetic cannabinoids, including some from the John W. Huffman (JWH) family, emerged on the drug scene around 2004 as "alternative marijuana," despite being considerably more potent than marijuana. Like Δ9-tetrahydrocannabinol (THC), the principal psychoactive ingredient in marijuana, synthetic cannabinoids have also been found to interact with cannabinoid receptors CB1 and CB2, found in the...
Fitoterapia
June 1, 2023
Caroline V. L. Moreira, Ana Luiza G Faria, Daiany P B Silva et al.
2 citations
Previous studies have attributed the prominent analgesic, hallucinogenic, sedative, and anxiolytic properties of Salvia divinorum to Salvinorin A. However, the overall pharmacological profile of this isolate limits its clinical applications. To address these limitations, our study evaluates the C(22)-fused-heteroaromatic analogue of salvinorin A [2-O-salvinorin B benzofuran-2-carboxylate]...
NeuroRegulation
September 29, 2022
Pankaj Pandey, Pragati Gupta, Krishna Prasad Miyapuram
10 citations
Research into the similarities and differences between various forms of meditation practice is still in its early stages. Here, utilizing functional connectivity and graph measures, we present our work examining three meditation traditions: Himalayan Yoga (HT), Isha Shoonya (SNY), and Vipassana (VIP). EEG activity of the meditative block is used to build functional brain connections to exploit...
arXiv Preprint Archive
June 12, 2021
Pankaj Pandey, Krishna Prasad Miyapuram
preprint
Several Convolutional Deep Learning models have been proposed to classify the cognitive states utilizing several neuro-imaging domains. These models have achieved significant results, but they are heavily designed with millions of parameters, which increases train and test time, making the model complex and less suitable for real-time analysis. This paper proposes a simple, lightweight CNN...
Journal of Psychopharmacology
July 2019
Adam W Keasling, Pankaj Pandey, Robert J Doerksen et al.
Salvinorin A is known as a highly selective kappa opioid receptor agonist with antinociceptive but mostly pro-depressive effects. In this article, we present its new semisynthetic analog with preferential mu opioid affinity, and promising antinociceptive, as well as antidepressant-like activities. Competitive binding studies were performed for salvindolin with kappa opioid and mu opioid. The...
Pankaj Pandey, Julio Rodriguez-Larios, Krishna Prasad Miyapuram et al.
Electroencephalography (EEG) enables online monitoring brain activity, which can be used for neurofeedback. One of the growing applications of EEG neurofeedback is to facilitate meditation practice. Specifically, EEG neurofeedback can be used to alert participants whenever they get distracted during meditation practice based on changes in their brain activity. In this study, we develop machine...