Ângelo de Fátima: research papers - The Consciousness Library

Psychedelic 25H-NBOMe attenuates post-sepsis depression in rats.

Neuroscience Letters June 21, 2024 Barbara G Ferri, Cintia O De Novais, Viviana C T Rojas et al. 3 citations

Sepsis-associated encephalopathy, which manifests in severe cognitive and depressive symptoms, is directly linked to neuroinflammation. Our study investigates the efficacy of 25H-NBOMe, a phenethylamine, in alleviating these symptoms, potentially offering an innovative treatment for post-sepsis depression. Wistar rats, weighing between 250-300 g, were subjected to cecal ligation and puncture...

DOI: 10.1016/j.neulet.2024.137845 Full text Animal models Forced swimming test Long-term sequelae Neuroinflammation +2

Exposure to the Psychedelic Substance 25H-NBOMe Disrupts Maternal Care in Lactating Rats and Subsequently Impairs the Social Play Behavior of the Offspring.

Behavioural Brain Research February 1, 2024 Larissa M.a. Melo, Wellington A De Barros, Ângelo de Fátima et al.

Given the critical role of maternal care in the neurodevelopment of offspring, this study aimed to investigate the effects of the psychedelic substance 25H-NBOMe on maternal behavior in lactating rats and its subsequent impact on the social and neurodevelopmental behavior of the offspring. We administered two different dosages of 25H-NBOMe (0.3mg/kg and 1.0mg/kg; i,p,) to lactating rats and...

DOI: 10.1016/j.bbr.2024.114924

Psychoactive substances 25H-NBOMe and 25H-NBOH induce antidepressant-like behavior in male rats.

European Journal of Pharmacology September 15, 2023 Barbara G Ferri, Cintia O De Novais, Raquel S Bonani et al. 11 citations

Ring-substituted phenethylamines are believed to induce psychedelic effects primarily by interacting with 5-hydroxytryptamine 2 (5-HT2A) receptors in the brain. We assessed the effect of the psychedelic substances 25H-NBOMe and 25H-NBOH on the depressive-like behavior of male adult rats. Naive Wistar rats were divided into groups to assess the effects of different doses (0.1 mg/kg, 1 mg/kg, and...

DOI: 10.1016/j.ejphar.2023.175926 Full text Depression Forced swimming test Psychedelics

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

Heliyon June 27, 2023 Larissa Marcely Gomes Cassiano, Marina da Silva Oliveira, Wellington Alves de Barros et al. 7 citations

Introduction: receptors. Although cases of toxicity associated with the recreational use of substituted phenethylamines are frequently reported, there is a lack of information on the possible neurotoxic effects of NBOMe and NBOH in the brain hippocampus, a major neurogenesis region. Objectives: This study aimed at assessing the phenotypic and molecular effects of prolonged exposure of the...

DOI: 10.1016/j.heliyon.2023.e17720

Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes

January 11, 2021 Wellington Alves de Barros, Marcelo P. Queiroz, L. D. da Silva et al.

Abstract An expeditious method is reported for the synthesis of three NBOHs (25H-, 25I- and 25B-NBOH; 9–38% overall yield) and three NBOMes (25H-, 25I- and 25B-NBOMe; 7–33% overall yield) from salicylaldehyde and 2-methoxyaldehyde, respectively. The X-ray structures of 25H-, 25I- and 25B-NBOH.HCl were also determined. Our approach should provide a general entry for preparing such a class of...

DOI: 10.1016/j.tetlet.2020.152804 Full text

Recreational drugs 25I-NBOH and 25I-NBOMe bind to both Sudlow's sites I and II of human serum albumin (HSA): biophysical and molecular modeling studies

New Journal of Chemistry 2021 Wellington Alves de Barros, Marina de Magalhães Silva, Maria Dayanne de Araújo Dantas et al.

25I-NBOH and 25I-NBOMe simultaneously bind to sites I and II of HSA, which may affect their distribution and effects.

DOI: 10.1039/d1nj00806d