The dissociative drug deschloroketamine was synthesized, and the absolute configuration of its enantiomers was determined. The in vitro cytotoxicity of each enantiomer was tested across nine different cell lines, providing data on their relative toxicities.
Methoxphenidine, a dissociative anesthetic related to phencyclidine, was originally patented for its potential to treat neurotoxic injury. The abstract indicates that the compound was developed with therapeutic applications in mind, specifically for addressing damage to the nervous system. No further details about its efficacy, mechanism, or clinical use are provided in this text.
The compounds 25I-NBOH and 25I-NBOMe both bind to two distinct sites (site I and site II) on human serum albumin (HSA), a protein that transports substances in the blood. This dual binding may influence how these compounds are distributed throughout the body and how they exert their effects.