Recreational drugs 25I-NBOH and 25I-NBOMe bind to both Sudlow's sites I and II of human serum albumin (HSA): biophysical and molecular modeling studies
Wellington Alves de Barros, Marina de Magalhães Silva, Maria Dayanne de Araújo Dantas, Josué Carinhanha Caldas Santos, Isis Martins Figueiredo, Otávio Augusto Chaves, Carlos Mauricio R. Sant’Anna, Ângelo de Fátima
New Journal of Chemistry January 1, 2021 DOI: 10.1039/d1nj00806d (opens in new tab)
Summary
AI-generated from the abstractThe compounds 25I-NBOH and 25I-NBOMe both bind to two distinct sites (site I and site II) on human serum albumin (HSA), a protein that transports substances in the blood. This dual binding may influence how these compounds are distributed throughout the body and how they exert their effects.
Study at a glance
| Characteristics | Peer reviewed |
|---|---|
| Key finding | 25I-NBOH and 25I-NBOMe simultaneously bind to sites I and II of HSA, potentially affecting their distribution and effects. |
Abstract
25I-NBOH and 25I-NBOMe simultaneously bind to sites I and II of HSA, which may affect their distribution and effects.