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Lukasz Smigielski

7 papers in the library · 520 citations · publishing 2019-2025

Papers

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A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research

Psychedelic Medicine January 20, 2025 Marianna Graziosi, Gabrielle Agin-Liebes, Mary P Cosimano et al. 9 citations

Introduction: Serotonergic psychedelics, serotonin 2A receptor agonists such as psilocybin that can result in substantially altered states of consciousness, are used in recreational and research settings. The safety of psychedelic experiences in research settings is supported by controlled physical environments, presence of clinical and medical staff to address emergent issues, screening for...

Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.

Scientific Reports March 26, 2024 Berit Singer, Daniel Meling, Matthias Hirsch-Hoffmann et al. 15 citations

In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before and after a five-day psilocybin-assisted meditation retreat using a recently established approach, based on the Mapper algorithm from topological data analysis. After generating subject-specific maps for two groups (psilocybin...

Comparing Neural Correlates of Consciousness: From Psychedelics to Hypnosis and Meditation

Biological Psychiatry Cognitive Neuroscience and Neuroimaging July 17, 2023 Flora Moujaes, Nathalie M. Rieser, Christophe Phillips et al. 19 citations

BACKGROUND: Pharmacological and nonpharmacological methods of inducing altered states of consciousness (ASCs) are becoming increasingly relevant in the treatment of psychiatric disorders. While comparisons between them are often drawn, to date no study has directly compared their neural correlates. METHODS: To address this knowledge gap, we directly compared 2 pharmacological methods...

P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

Human Brain Mapping August 21, 2020 Lukasz Smigielski, Michael Kometer, Milan Scheidegger et al. 42 citations

Abstract The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses its natural coherence offer a unique opportunity for elucidating the mechanisms underlying self‐disturbances. We assessed the...

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects.

Neuroimage August 1, 2019 Lukasz Smigielski, Milan Scheidegger, Michael Kometer et al. 261 citations

Both psychedelics and meditation exert profound modulatory effects on consciousness, perception and cognition, but their combined, possibly synergistic effects on neurobiology are unknown. Accordingly, we conducted a randomized, double-blind, placebo-controlled study with 38 participants following a single administration of the psychedelic psilocybin (315 μg/kg p.o.) during a 5-day mindfulness...