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Lars Michels

5 papers in the library · 217 citations · publishing 2017-2024

Papers

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Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.

Scientific Reports March 26, 2024 Berit Singer, Daniel Meling, Matthias Hirsch-Hoffmann et al. 15 citations

In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before and after a five-day psilocybin-assisted meditation retreat using a recently established approach, based on the Mapper algorithm from topological data analysis. After generating subject-specific maps for two groups (psilocybin...

Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences.

Scientific Reports October 14, 2023 Nathalie M. Rieser, Ladina P Gubser, Flora Moujaes et al. 14 citations

Research into the use of psilocybin for the treatment of psychiatric disorders is a growing field. Nevertheless, robust brain-behavior relationships linking psilocybin-induced brain changes to subjective drug-induced effects have not been established. Furthermore, it is unclear if the acute neural effects are dependent on individual heterogeneity in baseline characteristics. To address this, we...

Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis

Frontiers in Physiology February 11, 2020 Thomas A. W. Bolton, Diana Wotruba, Roman Buechler et al. 83 citations

Emerging evidence has attributed altered network coordination between the default mode, central executive, and salience networks (DMN/CEN/SAL) to disturbances seen in schizophrenia, but little is known for at-risk psychosis stages. Moreover, pinpointing impairments in specific network-to-network interactions, although essential to resolve possibly distinct harbingers of conversion to clinically...

Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow

Neuroimage July 12, 2017 Candace R. Lewis, Katrin H. Preller, Rainer Kraehenmann et al. 105 citations

Psilocybin, the active compound in psychedelic mushrooms, is an agonist of various serotonin receptors. Seminal psilocybin positron emission tomography (PET) research suggested regional increases in glucose metabolism in frontal cortex (hyperfrontality). However, a recent arterial spin labeling (ASL) study suggests psilocybin may lead to hypo-perfusion in various brain regions. In this...