Language helps organise experience into an idiosyncratic, temporally extended sense of self. We therefore used fMRI to investigate whether greater similarity between participants in the activity of language-associated brain regions accompanied psilocybin-induced loss of selfhood. Participants heard music and viewed moving clouds at baseline and after 19 mg psilocybin. At each brain location and...
Setting up a psychedelic study can be a long, arduous, and Kafkaesque process. Researchers are faced with a host of challenges in this rapidly evolving field, necessitating a range of considerations that remain largely unstandardised. Many of the complexities inherent to psychedelic research also challenge existing assumptions around, for example, approaches to psychiatric prescribing, the...
This study examines the existence and mechanistic underpinnings of lasting neural, cognitive, and behavioural plasticity in response to N-N-dimethyltryptamine (DMT) in a hazardous drinking population. It combines behavioural, neuroimaging, ecological momentary and qualitative data to gain a holistic understanding of potential mechanisms of therapeutic change following DMT. Primarily, we test...
Setting up a psychedelic study can be a long, arduous, and kafkaesque process. This rapidly-developing field poses several unique challenges for researchers, necessitating a range of considerations that have not yet been standardised. Many of the complexities inherent to psychedelic research also challenge existing assumptions around, for example, approaches to psychiatric prescribing, the...
Consciousness is often studied by asking whether particular brain regions or systems are privileged. We tested a distributed, decentred and context-sensitive alternative using 579 consciousness-focused neuroimaging studies. Semantic clustering of titles and abstracts identified seven domains whose corrected meta-analytic maps showed limited overlap and no invariant cross-domain core. These maps...