NeuroImage: Clinical
2022
Linnea Sepe-Forrest, Dae-Jin Kim, Patrick D Quinn et al.
Cerebellar-cortical resting-state functional connectivity (rsFC) has been reported to be altered in cannabis users. However, this association may be due to genetic and environmental confounding rather than a causal relationship between cannabis use and changes in rsFC. In this co-twin control study, linear mixed models were used to assess relationships between the number of lifetime cannabis...
Journal of Psychopharmacology
May 25, 2021
Ashley M. Schnakenberg Martin, Dae-Jin Kim, Sharlene D. Newman et al.
Background: Cannabis use has been associated with abnormalities in cerebellar mediated motor and non-motor (i.e. cognition and personality) phenomena. Since the cerebellum is a region with high cannabinoid type 1 receptor density, these impairments may reflect alterations of signaling between the cerebellum and other brain regions. Aims: We hypothesized that cerebellar-cortical resting-state...
Human Brain Mapping
January 2019
Dae-Jin Kim, Ashley M. Schnakenberg Martin, Yong-Wook Shin et al.
Cellular studies indicate that endocannabinoid type-1 retrograde signaling plays a major role in synaptic plasticity. Disruption of these processes by delta-9-tetrahydrocannabinol (THC) could produce alterations either in structural and functional brain connectivity or in their association in cannabis (CB) users. Graph theoretic structural and functional networks were generated with diffusion...
Neuropsychopharmacology
December 2014
Patrick D. Skosnik, Giri P Krishnan, Deepak C D'Souza et al.
Previous work in animals and humans has shown that exogenous cannabinoids disrupt time-locked, evoked gamma oscillations (30-80 Hz). However, no studies to date have examined the effect of cannabis on non-time-locked, induced gamma oscillations during more complex Gestalt perception. The current study therefore utilized electroencephalography (EEG) to examine gamma oscillations during coherent...
Journal of Psychopharmacology
November 2014
H Cheng, Patrick D. Skosnik, Ben J Pruce et al.
Chronic cannabis use can cause cognitive, perceptual and personality alterations, which are believed to be associated with regional brain changes and possible changes in connectivity between functional regions. This study aims to identify the changes from resting state functional magnetic resonance imaging scans. A two-level multi-voxel pattern analysis was proposed to classify male cannabis...
Journal of Psychopharmacology
June 2013
Daniel J Fridberg, Patrick D. Skosnik, William P Hetrick et al.
Chronic cannabis use is associated with residual negative effects on measures of executive functioning. However, little previous work has focused specifically on executive processes involved in performance monitoring in frequent cannabis users. The present study investigated event-related potential (ERP) correlates of performance monitoring in chronic cannabis users. The error-related...
Neuropsychopharmacology
September 2012
Patrick D. Skosnik, Deepak C D'Souza, Adam B. Steinmetz et al.
Animal and cellular work has shown that central cannabinoid-1 receptors modulate neural oscillations in the gamma range (40 Hz), which may be important for normal perceptual and cognitive processes. In order to assess the effect of cannabinoids on broadband-frequency neural oscillations in humans, the current study examined the effect of chronic cannabis use on auditory steady-state responses...
Brain Connectivity
2011
Dae-Jin Kim, Patrick D. Skosnik, Hu Cheng et al.
Endocannabinoid receptors modulate synaptic plasticity in the brain and may therefore impact cortical connectivity not only during development but also in response to substance abuse in later life. Such alterations may not be evident in volumetric measures utilized in brain imaging, but could affect the local and global organization of brain networks. To test this hypothesis, we used a novel...
Behavioral Neuroscience
August 1, 2009
Chad R. Edwards, Patrick D. Skosnik, Adam B. Steinmetz et al.
Central cannabinoid receptors are thought to mediate neural oscillations and are localized to brain regions implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study therefore examined if neural oscillations evoked by the paired clicks (S1, S2) are associated with impaired P50 gating reported in cannabis users. Seventeen heavy cannabis users and 16...