Hippocampal PACAP signaling activation triggers a rapid antidepressant response.
Military Medical Research July 23, 2024 Hai-Lou Zhang, Yan Sun, Zhang-Jie Wu et al. 24 citations
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...
DOI: 10.1186/s40779-024-00548-1 (opens in new tab)
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Ketamine
Antidepressant response
Optogenetic
Depression treatment
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