Hippocampal PACAP signaling activation triggers a rapid antidepressant response.
Military Medical Research July 23, 2024 Hai-Lou Zhang, Yan Sun, Zhang-Jie Wu et al. 24 citations
The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is investigated here to examine its role in mediating the rapid antidepressant response. The...