Psychopharmacology
October 2016
Zackary A Cope, Adam L. Halberstadt, Jordy Van Enkhuizen et al.
The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while responding prematurely before a light appears is suggested to reflect impulsivity/response...
Pharmacology, Biochemistry, and Behavior
March 1, 2000
Z A Martinez, N D Halim, J L Oostwegel et al.
NMDA antagonists and dopamine (DA) agonists produce neuropathological and/or behavioral changes in rats that may model specific abnormalities in schizophrenia patients. In adult rats, NMDA antagonists and DA agonists disrupt sensorimotor gating-measured by prepulse inhibition (PPI)-modeling PPI deficits in schizophrenia patients. In addition, high doses of NMDA antagonists produce limbic system...
Neuropsychopharmacology
July 1, 1999
Z A Martinez, G D Ellison, Mark A. Geyer et al.
Phencyclidine (PCP), a non-competitive NMDA antagonist with actions at multiple other central nervous system receptors, can cause both acute and lasting psychoses in humans, and has also been used in cross-species models of psychosis. Acute exposure to PCP in rats produces behavioral changes, including a loss of prepulse inhibition (PPI) of the startle reflex, which parallels the loss of PPI...
Behavioral and Brain Sciences
December 1, 1995
Neal R. Swerdlow
AbstractGray extrapolates from circuit models of psychopathology to propose neural substrates for the contents of consciousness. I raise three concerns: (1) knowledge of synaptic arrangements may be inadequate to fully support his model; (2) latent inhibition deficits in schizophrenia, a focus of this and related models, are complex and deserve replication; and (3) this conjecture omits...