Ontogeny of phencyclidine and apomorphine-induced startle gating deficits in rats.
Pharmacology, biochemistry, and behavior March 1, 2000 Z A Martinez, N D Halim, J L Oostwegel et al.
NMDA antagonists and dopamine (DA) agonists produce neuropathological and/or behavioral changes in rats that may model specific abnormalities in schizophrenia patients. In adult rats, NMDA antagonists and DA agonists disrupt sensorimotor gating-measured by prepulse inhibition (PPI)-modeling PPI deficits in schizophrenia patients. In addition, high doses of NMDA antagonists produce limbic system...