G D Ellison

2 papers in the library · publishing 1996-1999

Papers

Effects of sustained phencyclidine exposure on sensorimotor gating of startle in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology July 1, 1999 Z A Martinez, G D Ellison, M A Geyer et al.

Phencyclidine (PCP) can cause acute and lasting psychoses in humans and is used in animal models of psychosis. In rats, acute PCP disrupts prepulse inhibition (PPI) of the startle reflex, similar to deficits seen in schizophrenia. It was unclear whether sustained PCP exposure also disrupts PPI. This study gave rats PCP for 5 days via osmotic minipumps or for 14 days via repeated injections. PPI was disrupted only during drug administration, not after it stopped. PPI does not appear sensitive to the neuropathological effects of sustained PCP exposure.

DOI: 10.1016/s0893-133x(98)00137-7 Full text

Persisting changes in brain glucose uptake following neurotoxic doses of phencyclidine which mirror the acute effects of the drug.

Psychopharmacology August 1, 1996 G D Ellison, A S Keys

Phencyclidine (PCP) can cause a psychosis resembling schizophrenia and dementia that sometimes persists long after the drug is stopped. In rats, a five-day continuous 'binge' of PCP caused lasting increases in brain glucose metabolism, especially in limbic regions (retrosplenial, piriform, and entorhinal cortex, hippocampus, and olfactory tubercle). These increases were still present 10 days after the drug was removed, indicating that the metabolic changes persist. The findings suggest a brain basis for the prolonged psychosis that can follow PCP use.

DOI: 10.1007/bf02246457 Full text