Drug Design, Development and Therapy
January 1, 2024
Bo-Ran Deng, Yang Zhang, Zi-Feng Xie et al.
18 citations
In elderly patients undergoing painless colonoscopies, a combination of remimazolam and esketamine causes fewer drops in blood pressure and other hemodynamic complications than propofol plus esketamine. In a randomized trial with 754 patients, hypotension occurred in 9.78% of those given remimazolam-esketamine versus 23.57% in the propofol-esketamine group. The remimazolam group also had lower rates of sinus tachycardia, sinus bradycardia, and less need for blood-pressure-supporting drugs. Both sedative regimens achieved 100% sedation success, but the remimazolam combination led to a longer time to fall asleep yet faster recovery, along with less respiratory depression and injection pain. The findings indicate remimazolam with esketamine provides superior hemodynamic stability and safety for this population.
International journal of psychology : Journal international de psychologie
April 1, 2025
Rong Wang, Jingyi Zhou, Yang Zhang et al.
3 citations
Appreciative joy—taking delight in others' happiness—and gratitude are related but distinct emotions. A cross-sectional survey of adults found a moderate positive correlation between the two, and gratitude partly explained how appreciative joy relates to subjective well-being. A randomized controlled trial tested four weeks of appreciative joy meditation training. At a one-month follow-up, the training increased both appreciative joy and gratitude, and changes in gratitude were driven by changes in appreciative joy. Although subjective well-being improved immediately after the training, the data did not confirm that appreciative joy or gratitude caused that improvement. The findings clarify how Buddhist meditation practices may boost well-being through gratitude.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
March 20, 2025
Congli Zhang, Yan Yan, Junjie Ma et al.
1 citation
In a double-blind randomized trial, 82 frail elderly patients undergoing thoracoscopic radical resection of lung cancer received either intravenous esketamine or a placebo (normal saline) during surgery. Those given esketamine had significantly lower depression scores (HAMD-17) at 7 and 30 days after surgery, indicating less postoperative depression. They also reported better sleep quality in the first week and showed higher scores on a cognitive function test (MMSE) in the first month. Esketamine was associated with higher levels of serum BDNF and 5-HT, lower levels of S100β and NSE, reduced use of anesthetic drugs, fewer side effects like nausea and hyperalgesia, and shorter stays in the recovery room and hospital. Esketamine appears to improve postoperative depressive state, sleep, and cognitive function in this vulnerable group.
BMC Psychiatry
March 4, 2024
Jiali Dai, Dawei Sun, Bohui Li et al.
A mixed-mode version of Mindfulness-Based Cognitive Therapy (M-MBCT), combining face-to-face sessions with self-help components, improved psychological resilience and self-esteem and reduced stigma in 174 inpatients with schizophrenia. In an 8-week randomized controlled trial, those receiving M-MBCT showed significantly lower internalized stigma scores and higher resilience and self-esteem scores compared with those receiving standard treatment. Age, education, and family history of mental illness were associated with stigma levels. The findings suggest M-MBCT is an effective and potentially more accessible treatment option for people with schizophrenia.
Stress and health : journal of the International Society for the Investigation of Stress
February 1, 2024
Rong Wang, Xiaodan Gu, Yang Zhang et al.
Loving-kindness and compassion meditation (LKCM) reduces burnout, stress, and improves mindfulness, self-compassion, mental health, job attitudes, interpersonal relationships, and psychological resources among employees, based on a meta-analysis of 21 trials. Effect sizes ranged from small to moderate (g = 0.283 to 0.646). The benefits varied by participants' job type, gender, and the meditation's focus. The authors call for more research on long-term effects, underlying mechanisms, and organizational-level outcomes.