Anhedonia is frequently observed in Alzheimer's disease (AD) patients and is associated with a higher risk of cognitive decline and dementia, and it potentially serve as preclinical marker and psychopathological risk factor for AD. Current antidepressants show limited efficacy in anhedonia, highlighting a critical unmet medical need. In this study, APP/PS1 mice at 8 months of age exhibited...
ABSTRACT Anxiety is commonly present in medical students. Mindfulness can effectively treat anxiety, but the mechanisms are poorly understood. This study aimed to investigate the association between mindfulness and anxiety, and the mediation roles of intolerance of uncertainty (IU) and neuroticism. This cross-sectional study enrolled medical students from the Army Medical University in April...