Metabolite Profiling and Pathway Elucidation of 2-Fluorodeschloroketamine and 2-Fluoro-N-ethylketamine in Rats Using HPLC-QTOF Mass Spectrometry
Metabolites June 1, 2026 Yujie Zhang, Qing-Hong Wang, Yan-Jun Wang et al.
Highlights What are the main findings? A HPLC-QTOF/MS system was used to detect potential metabolites of 2-FDCK and 2-FXE in rats, determine metabolic pathways, and analyze metabolic differences. After single intraperitoneal injection administration of the drugs, samples were collected at 1 h and 2 h post-dosing. Metabolites were identified through database searches and secondary mass...