Baihong Guo

Ketamine metabolite HNK ameliorates anhedonia symptom in Alzheimer's disease mice.

Biochemical and Biophysical Research Communications September 17, 2026 Shuo Yang, Baihong Guo, Di Deng et al.

Anhedonia is frequently observed in Alzheimer's disease (AD) patients and is associated with a higher risk of cognitive decline and dementia, and it potentially serve as preclinical marker and psychopathological risk factor for AD. Current antidepressants show limited efficacy in anhedonia, highlighting a critical unmet medical need. In this study, APP/PS1 mice at 8 months of age exhibited...