Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse
JAMA Psychiatry April 28, 2016 Willem Kuyken, Fiona C Warren, Rod S Taylor et al. 815 citations
For people with recurrent depression, mindfulness-based cognitive therapy (MBCT) reduces the risk of depressive relapse within a 60-week follow-up period compared with usual care or other active treatments, including antidepressants. A meta-analysis of individual patient data from 9 randomized trials involving 1258 patients (mean age 47.1 years, 75% female) found that those receiving MBCT had a 31% lower risk of relapse versus no MBCT (hazard ratio 0.69), and a 21% lower risk versus other active treatments (hazard ratio 0.79). Sociodemographic and psychiatric variables did not significantly modify the treatment effect, but greater severity of depressive symptoms before treatment was associated with a larger benefit from MBCT.