JMIR Mental Health
June 16, 2026
Lorenzo Ghelfi, Jack Healy, Francesco Piacenza et al.
Abstract Background Psychotic disorder represents a leading cause of disability worldwide, and relapse in psychosis is common. Artificial intelligence (AI) is increasingly recognized as a method that could aid clinical monitoring for individuals experiencing psychosis. Objective This review aims to map the existing literature on AI-based approaches—including machine learning, deep learning, and...
Schizophrenia Bulletin
July 1, 2023
Lorna Staines, Colm Healy, Felim Murphy et al.
Background and hypothesis: Psychotic experiences (PEs) are associated with increased risk for mental disorders, in particular persistent PEs. PEs therefore might be useful within intervention research. We sought to systematically determine the incidence and persistence of PEs in the general population. Study design: A double-blind search of databases (Embase, Pubmed PMC, Psychinfo, Medline, and...
Early Intervention in Psychiatry
April 2019
Karen O' Connor, Barnaby Nelson, Mary Cannon et al.
The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with histories of childhood adversity (childhood trauma, bullying) and (3) perceptual...
Neuropsychopharmacology
October 2010
Colm M P O'Tuathaigh, Magdalena Hryniewiecka, Aine Behan et al.
Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high-low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20...
The British Journal of Psychiatry
August 31, 2010
Ian Kelleher, Jack A. Jenner, Mary Cannon
82 citations
Our ideas about the intrinsically pathological nature of hallucinations and delusions are being challenged by findings from epidemiology, neuroimaging and clinical research. Population-based studies using both self-report and interview surveys show that the prevalence of psychotic symptoms is far greater than had been previously considered, prompting us to re-evaluate these psychotic symptoms...
The British Journal of Psychiatry
January 30, 2004
Louise Arseneault, Mary Cannon, John Witton et al.
924 citations
BACKGROUND: Controversy remains as to whether cannabis acts as a causal risk factor for schizophrenia or other functional psychotic illnesses. AIMS: To examine critically the evidence that cannabis causes psychosis using established criteria of causality. METHOD: We identified five studies that included a well-defined sample drawn from population-based registers or cohorts and used prospective...