JMIR Mental HealthJune 16, 2026Lorenzo Ghelfi, Jack Healy, Francesco Piacenza et al.
Abstract Background Psychotic disorder represents a leading cause of disability worldwide, and relapse in psychosis is common. Artificial intelligence (AI) is increasingly recognized as a method that could aid clinical monitoring for individuals experiencing psychosis. Objective This review aims to map the existing literature on AI-based approaches—including machine learning, deep learning, and...
Background and hypothesis: Psychotic experiences (PEs) are associated with increased risk for mental disorders, in particular persistent PEs. PEs therefore might be useful within intervention research. We sought to systematically determine the incidence and persistence of PEs in the general population. Study design: A double-blind search of databases (Embase, Pubmed PMC, Psychinfo, Medline, and...
NeuropsychopharmacologyOctober 2010Colm M P O'Tuathaigh, Magdalena Hryniewiecka, Aine Behan et al.
Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high-low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20...