Perceptual abnormalities in an ultra-high risk for psychosis population relationship to trauma and co-morbid disorder.
Karen O' Connor, Barnaby Nelson, Mary Cannon, Alison R Yung, Andrew Thompson
Early Intervention in Psychiatry April 2019 DOI: 10.1111/eip.12469 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cross-sectional study Peer reviewed |
|---|---|
| Sample size | 118 |
| Population | Young people entering an ultra-high risk (UHR) clinic |
| Keywords | Hallucinations Psychosis Trauma Ultra high risk |
| Key findings | At entry to a UHR clinic, depressive disorder was associated with increased odds of perceptual abnormalities (OR 3.59), especially visual (OR 2.36); borderline personality disorder with auditory abnormalities (OR 3.44), particularly second-person (OR 2.69); and childhood trauma (OR 6.30) and bullying (OR 5.00) with perceptual abnormalities. The authors suggest certain perceptual abnormalities may index risk for co-morbid non-psychotic disorder and prior childhood trauma. |
Abstract
The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with histories of childhood adversity (childhood trauma, bullying) and (3) perceptual abnormality type is associated with co-morbid psychiatric diagnoses or histories of childhood adversity. In a sample of 118 UHR patients we investigated the relationship between perceptual abnormalities and non-psychotic diagnoses and adverse life events at entry to a UHR clinic. Depressive disorder at baseline was associated with increased odds of experiencing perceptual abnormalities (OR 3.59, P = .004), particularly visual perceptual abnormalities (OR 2.36, P = .02). Borderline personality disorder at baseline was associated with increased odds of any auditory perceptual abnormalities (OR 3.44, P = .04) and specifically second person perceptual abnormalities (OR 2.69, P = .04). A history of childhood trauma and childhood bullying were both associated with increased odds of experiencing perceptual abnormalities at baseline (trauma OR 6.30, P < .001; bullying OR 5.00, P = .01). Our findings suggest that in the UHR population, certain types of perceptual abnormalities index risk for co-morbid non-psychotic disorder and indicate prior experience of childhood trauma. The use of detailed phenomenology of psychotic symptoms can help to shape our understanding of risk in UHR patients.