Psychology and Psychotherapy Theory Research and Practice
March 2022
Kate Williams, Samantha Hartley, Ian M. Anderson et al.
Mindfulness-based cognitive therapy (MBCT) is an 8-week relapse-prevention intervention designed for people who have experienced multiple episodes of depression and remain vulnerable to relapse. Previous qualitative explorations of the effects of MBCT for people in remission from depression have suggested a number of themes regarding changes arising from participating in MBCT ranging from...
Mindfulness
March 1, 2021
Kate Williams, Rebecca Elliott, Thorsten Barnhofer et al.
Abstract Objectives A combination of negatively biased information processing and a reduced ability to experience positive emotions can persist into remission from major depression (rMDD). Studies have shown that mindfulness-based cognitive therapy (MBCT) can increase self-reported positive emotions in rMDD participants; similar changes using neuropsychological tasks have not been shown. In...
Psychiatry Research Neuroimaging
July 23, 2020
K. Williams, Rebecca Elliott, S. Mckie et al.
Mindfulness-Based-Cognitive-Therapy (MBCT) reduces vulnerability for relapse into depression by helping individuals to counter tendencies to engage in maladaptive repetitive patterns of thinking and respond more compassionately to negative self-judgment. However, little is known about the neural correlates underlying these effects. To elucidate these correlates, we investigated fMRI brain...
The Lancet Psychiatry
May 1, 2017
I. Anderson, Andrew M. Blamire, Tim Branton et al.
106 citations
Summary Background The use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effects. Preliminary evidence suggests that administering the glutamate antagonist ketamine with ECT might alleviate cognitive adverse effects and accelerate symptomatic improvement; we tested this in a randomised trial of low-dose ketamine. Methods In this multicentre, randomised,...
Efficacy and Mechanism Evaluation
March 1, 2017
Ian M. Anderson, Andrew M. Blamire, Tim Branton et al.
15 citations
Background Electroconvulsive therapy (ECT) is the most effective acute treatment for severe depression, but there are concerns about its adverse cognitive effects. ECT may impair cognition through stimulation of glutamate receptors, and preliminary evidence has suggested that ketamine, a glutamate antagonist, may alleviate these effects. Ketamine has been shown to have a rapid, but temporary,...