I. Anderson

2 papers in the library · 106 citations · publishing 2017-2020

Papers

Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial

Lancet Psychiatry May 1, 2017 I. Anderson, A. Blamire, T. Branton et al. 106 citations

Adding a low dose of the drug ketamine to the anesthetic used during electroconvulsive therapy (ECT) does not improve memory or speed recovery in severely depressed patients. In a randomized trial of 79 patients, those who received ketamine scored no better on a test of delayed verbal recall after four ECT sessions than those who received a placebo (saline). The ketamine group actually scored slightly lower on average, and the results rule out any more than a small to moderate benefit. Patients receiving ketamine also reported more adverse events, including transient psychological effects. The findings do not support using ketamine as a routine addition to ECT.

DOI: 10.1016/s2215-0366(17)30077-9 Full text Medicine

Changes in the neural correlates of self-blame following mindfulness-based cognitive therapy in remitted depressed participants.

Psychiatry research. Neuroimaging July 23, 2020 K. Williams, R. Elliott, S. Mckie et al.

After mindfulness-based cognitive therapy (MBCT), people in remission from major depressive disorder showed reduced brain activation in the bilateral dorsal anterior cingulate and medial superior frontal gyrus when blaming themselves compared to blaming others. Increased self-kindness after MBCT correlated with reduced activation in the posterior cingulate cortex and precuneus during self-blame. These findings suggest MBCT may alter neural responses to self-blame, possibly through increasing self-kindness. The study was small, with 16 participants, and lacked a control group, so results require confirmation.

DOI: 10.1016/j.pscychresns.2020.111152 Full text Psychology Medicine