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Fiona Macpherson

4 papers in the library · 4 citations · publishing 2025-2026

Papers

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Stroboscopic Light Stimulation in Adults Reporting Depressive Symptoms: Safety, Tolerability, Feasibility, and Active-Comparator Development in a Staged Early-Phase Study

medRxiv Preprint Server June 17, 2026 Danny Nacker, Luise Kalus, Anil K. Seth et al. preprint

Stroboscopic light stimulation (SLS) is a candidate non-pharmacological intervention that induces transient visual and affective experiences, with potential application in depression. Before efficacy testing, clinical development requires safety, tolerability and feasibility data. We report a staged, single-site programme in adults reporting depressive symptoms. Work Package (WP) 1 tested 11...

A Large-Scale Computer-Vision Mapping of the Geometric Structures of Stroboscopically-Induced Visual Hallucinations

bioRxiv (Cold Spring Harbor Laboratory) February 18, 2026 Ethan Grove, Trevor Hewitt, Anil K. Seth et al. 1 citation

Abstract Visual hallucinations (VHs) occur across psychedelic states and diverse psychiatric and neurological conditions, yet their phenomenology remains difficult to characterise. Empirical research on VHs is hindered by the lack of large-scale phenomenological datasets, which limits both mechanistic accounts and the systematic characterisation of when and how they arise. Stroboscopic light...

Mapping of Subjective Accounts into Interpreted Clusters (MOSAIC): Topic Modelling and LLM applied to Stroboscopic Phenomenology

arXiv Preprint Archive February 25, 2025 Romy Beauté, David J. Schwartzman, Guillaume Dumas et al.

Stroboscopic light stimulation (SLS) on closed eyes typically induces simple visual hallucinations (VHs), characterised by vivid, geometric and colourful patterns. A dataset of 862 sentences, extracted from 422 open subjective reports, was recently compiled as part of the Dreamachine programme (Collective Act, 2022), an immersive multisensory experience that combines SLS and spatial sound in a...