bioRxiv
August 20, 2026
Ilknur Kayikcioglu Bozkir, Ryan Lashin, Tiecheng Liu et al.
preprint
Psilocybin is a psychedelic which has been shown to induce neural plasticity through activation of intracellular serotonergic 5-HT2A receptors. It also produces brain-wide changes in structural and functional connectivity and holds promise as a therapeutic compound for treating anxiety and depression. Despite links between psilocybin-induced plasticity, the psychedelic experience, and reduction...
Journal of Clinical and Translational Science
April 1, 2026
Emma R. Huels, S. Smith, Tiecheng Liu et al.
Objectives/Goals: We recently showed that a single dose of psilocybin, a serotonergic psychedelic, attenuated mechanical hypersensitivity for up to 28 days in a rat model of formalin-induced chronic centralized pain. The goal of this study is to determine whether psilocybin can alleviate chronic pain in a rat model of reserpine-induced chronic centralized pain. Methods/Study Population: Adult...
Physiology
May 1, 2025
Andres Villegas Calderon, Emma R. Huels, Amanda Nelson et al.
Serotonergic psychedelics are being explored as therapeutic agents for mental health disorders and have also been shown to promote wakefulness. In a recently completed study (reported as preliminary findings), we showed that intravenous administration of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a classic serotonergic psychedelic, can induce wakefulness and reverse the state of anesthesia produced...
Anesthesiology
February 26, 2021
D. Pal, George A. Mashour
Although the precise neural correlates of consciousness have not yet been identified, there is one neurochemical marker that appears to track with our capacity to experience something: acetylcholine concentration in the cerebral cortex. Cortical acetylcholine concentration is high during wakefulness, decreases during slow-wave sleep, and increases again during rapid eye movement sleep, when we...
September 9, 2015
D. Pal
The hibernation and the ‘Vital Living Force’ (~ = Prâna) that, in turn, is responsible for maintaining the "life function" can be explained through the developed consciousness model involving thought-carrying particles (TCP), thought retaining particles (TRP) and thought force (TF). Our consciousness model signifies the existence of universal consciousness that exists along with the universe....
July 17, 2012
D. Pal, A. De
We developed a consciousness model. Our consciousness model incorporating Thought-carrying particle (TCP), Thought-retaining particle (TRP) and Thought Force (TF) signifies the existence of the universal consciousness that exists along with the universe. The universal consciousness is a functional state of the universal mind (UM). We indicated the existence of thought force (TF) that is an...
September 7, 2007
A. De, D. Pal
The thought force a manifestation of universal consciousness, has been shown to be carried by thought-carrying particle in the inherent presence of thought retaining particle in a previous communication (Pal et al., 2004). The thought force (TF) is the origin of all the existing fields. While TCP is the origin of all the field particles (bosons), TRP is the origin of all the matter particles...