Serotonergic psychedelics are being explored as therapeutic agents for mental health disorders and have also been shown to promote wakefulness. In a recently completed study (reported as preliminary findings), we showed that intravenous administration of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a classic serotonergic psychedelic, can induce wakefulness and reverse the state of anesthesia produced...
Serotonergic psychedelics enhance neurophysiological complexity and the repertoire of brain states, whereas general anesthetics produce opposite effects. Serotonergic psychedelics are also known to increase wakefulness and reduce sleep time in rodents. Therefore, we hypothesized that 2,5-dimethoxy-4-iodopamphetamine (DOI), a serotonergic psychedelic, will reverse general anesthesia and restore...