Scientific Data
January 9, 2026
Zirui Huang, Vijay Tarnal, Panagiotis Fotiadis et al.
Anesthesia has revolutionized surgical practice and offers a controlled model to study the neurobiology of consciousness. Functional magnetic resonance imaging (fMRI) studies have shown that anesthesia primarily disrupts connectivity across association cortices, suggesting that impaired integration between higher-order brain regions underlies unconsciousness. However, traditional fMRI paradigms...
Commun Biol
December 19, 2023
Rui Dai, Zirui Huang, Tony E. Larkin et al.
7 citations
Psychedelic concentrations of nitrous oxide reduce functional differentiation in frontoparietal and somatomotor cortical networks.
Neuroimage
June 1, 2023
Rui Dai, Tony E. Larkin, Zirui Huang et al.
49 citations
The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT2 receptor) and non-classical psychedelics would provide mechanistic insight into state-specific characteristics. We analyzed whole-brain functional connectivity based on resting-state fMRI data in humans, acquired before and during...
Neuroimage
May 14, 2021
Catherine Duclos, Charlotte Maschke, Yacine Mahdid et al.
The development of sophisticated computational tools to quantify changes in the brain's oscillatory dynamics across states of consciousness have included both envelope- and phase-based measures of functional connectivity (FC), but there are very few direct comparisons of these techniques using the same dataset. The goal of this study was to compare an envelope-based (i.e. Amplitude Envelope...
Cell Reports
May 1, 2021
Zirui Huang, Vijay Tarnal, Phillip E. Vlisides et al.
119 citations
Conscious access to sensory information is likely gated at an intermediate site between primary sensory and transmodal association cortices, but the structure responsible remains unknown. We perform functional neuroimaging to determine the neural correlates of conscious access using a volitional mental imagery task, a report paradigm not confounded by motor behavior. Titrating propofol to loss...
Scientific Reports
February 16, 2021
Catherine Duclos, Danielle Nadin, Yacine Mahdid et al.
28 citations
Motifs are patterns of inter-connections between nodes of a network, and have been investigated as building blocks of directed networks. This study explored the re-organization of 3-node motifs during loss and recovery of consciousness. Nine healthy subjects underwent a 3-h anesthetic protocol while 128-channel electroencephalography (EEG) was recorded. In the alpha (8-13 Hz) band, 5-min epochs...
British Journal of Anaesthesia
April 13, 2018
Phillip E. Vlisides, Tarik Bel‐bahar, Amanda Nelson et al.
117 citations
BackgroundDespite its designation as a 'dissociative anaesthetic,' the dissociative and psychoactive effects of ketamine remain incompletely understood. The goal of this study was to characterise the subjective experiences and accompanying EEG changes with subanaesthetic doses of ketamine.MethodsHigh-density EEG was recorded in 15 human volunteers before, during, and after subanaesthetic...