European Neuropsychopharmacology
April 10, 2026
Deborah Rudin, Jan Valenta, Helene Rolli et al.
2 citations
Serotonergic psychedelics primarily exert their effects through activation of the serotonin (5-HT) 2A receptor (5-HT 2A R). However, the full pharmacological profiles of these substances involve multiple serotonin receptor subtypes and intracellular signaling pathways. This study characterized the signaling behavior of a panel of serotonergic psychedelics using stable cell lines and a series of...
Acta Neuropsychiatrica
April 10, 2026
Ashkan Veysi, Daniela Atanasovski, Maryam Ardalan et al.
Psychedelics such as psilocybin are known for their hallucinogenic properties and have also been reported to produce long-lasting therapeutic effects in depression and possibly also other psychiatric disorders. Several lines of evidence suggest that psilocybin exerts its effects through activation of 5-HT2A receptors located postsynaptically to serotonergic neurons, for example, in the frontal...
Psychiatria Danubina
April 2026
Arif de Mendelssohn, Henriette Löffler-stastka
The history of mental science is marked by a divide between the subjective, energetic models of psychoanalysis and the objective models of computational neuroscience. Reductionist approaches often fail to bridge this gap or adequately explain the structural complexity of psychopathology. This conceptual synthesis aims to propose a unified, testable neurocomputational framework anchored in the...
Vavilovskii zhurnal genetiki i selektsii
April 1, 2026
Andrey V. Bocharov, Alexander N. Savostyanov, Sergey Tamozhnikov et al.
Serotonin transporter gene polymorphism is important in the regulation of the serotoninergic system that affects mood and the regulation of emotions and behavior. In this study, 128 channel electroencephalogram recordings were performed, and buccal epithelium samples were obtained from 53 volunteers (32 females). La , Lg , and S alleles were identified by polymerase chain reaction. The aim of...
Journal of Neurophysiology
April 1, 2026
Inga Griškova-bulanova, Čestmír Vejmola, Tomáš Páleníček
Auditory steady-state responses (ASSRs), particularly at 40 Hz, are promising biomarkers for psychiatric disorders involving dysregulated neural synchronization. Although most ASSR studies have focused on the glutamatergic system, the serotonergic system, specifically 5-HT2A receptor signaling, has received limited attention. Psilocin, the active metabolite of psilocybin and a known 5-HT2A...
bioRxiv (Cold Spring Harbor Laboratory)
March 23, 2026
Marco Taddei-Tardón, Lidia Medina-Rodríguez, Jessica L Maltman et al.
preprint
Abstract Serotonergic psychedelics have attracted considerable interest as promising therapeutic agents. However, the molecular mechanisms linking their acute hallucinogenic-like effects to longer-lasting neuroplastic responses remain incompletely understood, partly because of the scarcity of native neural models suitable for mechanistic studies. Here, we developed a neural stem cell-derived in...
ACS Chemical Neuroscience
March 20, 2026
Eline Pottie, Emma Vertriest, Darío Martínez-afani et al.
N-Benzyl-derived phenethylamines are highly active (psychedelic) 5-HT2AR (serotonin 2A receptor) agonists used as biochemical tools and on the drug market. The impact of adding an N-benzyl substituent to the tryptamine core structure has scarcely been studied. A recent systematic exploration of N-benzyl-substituted (5-MeO-)tryptamines revealed a surprisingly low activity in a Ca2+ mobilization...
Molecules and Cells
March 10, 2026
Victoria N. Chang, Roberto Ogelman, R. Vargas et al.
1 citation
Excitatory synapse plasticity at postsynaptic dendritic spines is directly modulated through neurotransmitter signaling. Serotonin (5-HT) is a primary neuromodulator in the brain that activates 14 subtypes of G-protein-coupled receptors, each with distinct expression patterns and downstream signaling mechanisms. Disruptions of serotonergic transmission during development and adulthood induce...
Psychopharmacology
March 4, 2026
Ava M. Mac, Srinivasu Kallakuri, Alixandria T. Mascarin et al.
MDMA (3–4 methylenedioxymethamphetamine) assisted psychotherapy has gained considerable attention as a potential adjuvant therapy for post-traumatic stress disorder (PTSD). Reports of the nonmedical use of MDMA suggest its adverse effects may include anxiety and anhedonia. However, the time course of these signs and symptoms and the potential alterations in neurotransmitter levels that may...
Molecular Psychiatry
March 1, 2026
Tyler G. Ekins, Chloe Rybicki-Kler, Tao Deng et al.
9 citations
Classical psychedelic drugs show promise as a treatment for major depressive disorder and related psychiatric disorders. This therapeutic efficacy stems from long-lasting psychedelic-induced neuroplasticity onto prefrontal cortical neurons and is thought to require the postsynaptic expression of serotonin 2A receptors (5-HT_2AR). However, other cortical regions such as the granular...