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Marco Taddei-Tardón

4 papers in the library · publishing 2025-2026

Papers

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A signaling signature distinguishes hallucinogenic from non-hallucinogenic psychedelics

Translational Psychiatry September 1, 2026 Sandra M. Martin-Guerrero, Marco Taddei-Tardón, Jessica L. Maltman et al.

Abstract Psychedelic drugs can induce intense changes in perception and thought, and some also promote long-lasting adaptations in brain circuits that are being explored for treatment of mood and anxiety disorders. How these compounds differ at the level of intracellular signaling, and how hallucinogenic drugs diverge from related non-hallucinogenic forms, is poorly understood. A central...

Integrated 5-HT2A-TrkB and G protein signaling in serotonergic psychedelic responses.

Molecular Psychiatry July 16, 2026 Marco Taddei-Tardón, Lidia Medina-Rodríguez, Jessica L Maltman et al.

Serotonergic psychedelics have attracted considerable interest as promising therapeutic agents. However, the molecular mechanisms linking their acute hallucinogenic-like effects to longer-lasting neuroplastic responses remain incompletely understood, partly because of the scarcity of native neural models suitable for mechanistic studies. Here, we developed a neural stem cell-derived in vitro...

Integrated 5-HT 2A –TrkB and G protein signaling in serotonergic psychedelic responses

bioRxiv (Cold Spring Harbor Laboratory) March 23, 2026 Marco Taddei-Tardón, Lidia Medina-Rodríguez, Jessica L Maltman et al.

Abstract Serotonergic psychedelics have attracted considerable interest as promising therapeutic agents. However, the molecular mechanisms linking their acute hallucinogenic-like effects to longer-lasting neuroplastic responses remain incompletely understood, partly because of the scarcity of native neural models suitable for mechanistic studies. Here, we developed a neural stem cell-derived in...

Quantitative phosphoproteomics uncovers the signalling dynamics of hallucinogenic psychedelics.

bioRxiv : the preprint server for biology November 26, 2025 Sandra M. Martin-Guerrero, Marco Taddei-Tardón, Jessica L Maltman et al. preprint

Psychedelic drugs can induce intense changes in perception and thought, and some also promote long-lasting adaptations in brain circuits that are being explored for treatment of mood and anxiety disorders. How these compounds differ at the level of intracellular signalling, and how hallucinogenic drugs diverge from related non-hallucinogenic forms, is poorly understood. A central question is...