June 10, 2021
P. Michael, David Luke, Oliver Robinson
1 citation
preprint
Introduction: N, N-Dimethyltryptamine (DMT) is an endogenous serotonergic psychedelic capable of producing radical shifts in conscious experience. Increasing trends in its use, as well as new trials administering DMT to patients, indicate the growing importance of a thorough elucidation of the phenomenology the drug may occasion. This is particularly in light of the hyper-real, otherworldly,...
Cerebral Cortex
June 10, 2021
Patricia Duerler, Silvia Brem, Gorka Fraga González et al.
64 citations
Abstract As source of sensory information, the body provides a sense of agency and self/non-self-discrimination. The integration of bodily states and sensory inputs with prior beliefs has been linked to the generation of bodily self-consciousness. The ability to detect surprising tactile stimuli is essential for the survival of an organism and for the formation of mental body representations....
BJPsych Open
June 1, 2021
Amber Elyse Corrigan, Ella Burchill, Lucy Pelton et al.
1 citation
Aims Depression is the single largest contributor to global disability. However, effective treatments are currently lacking, resulting in a significant burden of treatment-resistant depression (TRD). Psilocybin, a serotonergic psychedelic, found as the active compound in 'magic mushrooms', has been proposed as a novel therapeutic avenue for TRD. We aimed to evaluate the future feasibility and...
World Psychiatry
May 18, 2021
Wayne Hall
17 citations
A psychedelic drug is one that “produces thought, mood and perceptual changes otherwise rarely experienced except in dreams, contemplative and religious exaltation, flashes of vivid involuntary memory, and acute psychosis”1. It does so “without causing physical addiction, craving, major physiological disturbances, delirium, disorientation or amnesia”1. The “classic psychedelics” include...
Cureus
May 17, 2021
Sarah Tedesco, Ganeya Gajaram, Shahzad Chida et al.
31 citations
Background: 3,4-methylenedioxymethamphetamine (MDMA), known recreationally as "Molly" or "Ecstasy", is a triple monoamine reuptake inhibitor. MDMA specifically acts as a weak 5-HT1 and 5-HT2 receptor agonist, targeting 5-HT2A, 5-HT2B, and 5-HT2C receptors. Its potential use for therapeutic purposes with these pharmacological profiles remains a controversial subject. Studies have shown the...
Pharmacopsychiatry
May 12, 2021
Gerhard Gründer, Henrik Jungaberle
32 citations
Abstract Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide (LSD), or dimethyltryptamine (DMT), as well as psychoactive drugs that trigger phenomenologically- related experiences like 3,4-methylenedioxymethamphetamine (MDMA) and ketamine, belong to the most promising treatment approaches in contemporary psychiatry. Psychedelic-assisted psychotherapy is not only a new...
Brazilian Journal of Health Review
May 3, 2021
Fabiana Venancio Santana Silva, Alexandre Libanio Silva Reis, Amanda Prazeres Costa et al.
Dados da Organização Mundial de Saúde (OMS) informam que a depressão circunda entre as doenças mais incapacitantes do mundo, estimando-se que mais de 300 milhões de pessoas sofram com esta patologia. A psilocibina é um princípio ativo extraído do cogumelo do gênero Psilocybe de natureza química semelhante ao neurotransmissor serotonina (5- hidroxitriptamina) e a sua ação fisiológica em humanos...
The FASEB Journal
May 1, 2021
Alison Wakeford, Marissa Costa, Hannah Alton et al.
Previous preclinical studies have demonstrated that 3,4‐methylenedioxymethamphetamine (MDMA) dose‐dependently increases pro‐social behavior and affiliative vocalizations in male nonhuman primates. As diagnostic criteria for several psychiatric diseases includes deficits in social functioning, examining the conditions under which MDMA selectively increases pro‐social behavior may provide...
Suchttherapie
May 1, 2021
[ Abb. 1 ] zeigt die Strukturformel, die Anwendungsarten und die handelsüblichen Formen von DMT (Dimethyltryptamin). Substanz Tryptaminhaltige Pflanzen wurden über mehrere 1000 Jahre von südamerikanischen Ureinwohnern bei religiösen Ritualen und zu medizinischen Zwecken eingenommen. Ziel dabei war die Provokation visionärer Erlebnisse als Kontaktaufnahme mit einer jenseitigen Welt, z. B. um die...
Journal of Psychiatric Research
May 1, 2021
Bruno Romeo, Marianne Hermand, Amélie Pétillion et al.
74 citations
The use of psychedelic treatments has shown very promising results in some psychiatric and addictive disorders, but not all patients achieved a response. The aim of this review is to explore the clinical and biological factors which could predict the response to psychedelics in psychiatric and addictive disorders. A systematic research was performed on MEDLINE, PsycInfo, Web of science, and...