Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy
Lubo Zhang, Donald C. Dyer
European Journal of Pharmacology January 5, 1993 DOI: 10.1016/0014-2999(93)90420-m (opens in new tab)
Study at a glance
AI-extracted from the abstractAbstract
d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cites 3
- Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. Journal of Pharmacology and Experimental Therapeutics September 1, 1988
- Characterisation of [3H]lysergic acid diethylamide binding to a 5-hydroxytryptamine receptor on human platelet membranes European Journal of Pharmacology 1984
- Antagonism of 5-hydroxytryptamine2 receptor-mediated phosphatidylinositol turnover by d-lysergic acid diethylamide. Journal of Pharmacology and Experimental Therapeutics December 1, 1988