Salvia divinorum is a vision-inducing mint used by the Mazatec people of Oaxaca, Mexico. It is grown in California and other parts of the United States where it is employed as a legal hallucinogen. Traditional opinion has been that the plant has mild psychotropic activity, at best. However, when ingested in the correct manner, it is quite powerful. The fresh leaves are chewed as a quid and kept...
Abstract The absolute stereostructures of the hallucinogenic diterpenes salvinorin A and B have been unambiguously determined by the use of the non-empirical exciton chirality circular dichroism method on their 1α,2α-diol dibenzoate derivative.
AbstractDivinorin A (Ia), das erste eindeutig als gsxchoo trop erkannte Terpenoid, und Divinorin B, beide aus dem Lippenblütler Salvia divinorum (Mexikanische Hinze), werden hinsichtlich ihrer Strukturen sichergestellt.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDivinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorumLeander J. Valdes III, William M. Butler, George M. Hatfield, Ara G. Paul, and Masato KoreedaCite this: J. Org. Chem. 1984, 49, 24, 4716–4720Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published...
Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs, the morning glory, Rivea corymbosa L., Hallier f. and the psilocybin-containing mushrooms. A discussion of the role of ska María Pastora in the native "pharmacopeia"...
The past decade has been characterised by a resurgence in psychedelic research seeking to treat mental health issues, which claim over 700,000 lives each year. Salvinorin A, the main psychoactive substituent of Salvia divinorum, is a novel psychedelic distinct from those currently in clinical trials, presenting a unique avenue for further developments in psychopharmacology. In this essay, the...
The salvinorins serve as templates for next generation analgesics, antipruritics and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selectivity via complex polyoxygenated scaffolds that have frustrated deep-seated modification by synthesis. Here we...
The salvinorins represent a unique class of polyoxygenated, non-nitrogenous diterpenes that potently and selectively modulate the kappa-opioid receptor (KOR). We recently disclosed a de novo asymmetric synthesis of this scaffold that enabled the discovery of highly potent, biased analogs, including C11-alkynes designed for the CATCH (Clearing-Assisted Tissue Click Chemistry) assay. Here, we...
Salvia species native to the Americas are rich in valuable bioactive furanoclerodanes like the psychoactive salvinorin A found in Salvia divinorum, which is used in the treatment of opioid addiction. However, relatively little is known about their biosynthesis. To address this, we investigated the biosynthesis of salviarin, the most abundant furanoclerodane structure in the ornamental sage...
There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression. Despite promising efficacy observed in some clinical trials, the full range of biological effects and mechanism(s) of action of these compounds...