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Salvia divinorum: all studies

Page 26 of 41: studies 251 to 260 of 407, newest first. Back to the salvia divinorum overview

Research

Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors.

Psychopharmacology May 1, 2005 Yong Zhang, Eduardo R Butelman, Stefan D Schlussman et al. 198 citations

Salvinorin A is a naturally occurring hallucinogen derived from the plant Salvia divinorum. Salvinorin A is also a potent and selective kappa opioid receptor agonist in vitro. It has been shown that kappa agonists decrease dopamine levels in the caudate putamen and nucleus accumbens and cause conditioned place aversion in rodents. To study the effects of salvinorin A on basal dopamine levels in...

DOI: 10.1007/s00213-004-2087-0 (opens in new tab) Full text (opens in new tab) Salvinorin a Dopamine regulation Kappa opioid receptors Behavioral effects

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist.

Journal of Medicinal Chemistry January 27, 2005 Thomas A Munro, Mark A Rizzacasa, Bryan L. Roth et al.

Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective kappa opioid receptor (KOR) agonist. We screened other salvinorins and derivatives for binding affinity and functional activity at opioid receptors. Our results suggest that the methyl ester and furan ring are required for activity but that the lactone and ketone functionalities are not. Other salvinorins showed...

DOI: 10.1021/jm049438q (opens in new tab) Full text (opens in new tab)

Use of nonprohibited hallucinogenic plants: increasing relevance for public health? A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage).

Pharmacopsychiatry 2005 R Bücheler, C H Gleiter, P Schwoerer et al. 63 citations

: We want to call attention to a mint plant, called diviner's sage ( Salvia divinorum), originally used in shamanic ceremonies of the Mazatec Indians of Mexico. On numerous websites of the internet, this ancient herbal drug and its extracts are offered as a legal means of widening individual awareness. Regarding its dose-response relationship, the active ingredient, salvinorin A, is one of the...

DOI: 10.1055/s-2005-837763 (opens in new tab) Full text (opens in new tab) Diviner's sage Potent hallucinogens Health professionals Public health questions +9

A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A.

Bioorganic & Medicinal Chemistry Letters October 18, 2004 Kevin Tidgewell, Wayne W Harding, Mark S Schmidt et al. 68 citations

Salvinorin A is a novel hallucinogen isolated from the widely available leaves of Salvia divinorum. Based on its mechanism of action, salvinorin A has shown potential as a stimulant abuse therapeutic. However, there are no methods for the detection of salvinorin A or its metabolites in biological fluids. In order to begin developing salvinorin A as a potential therapeutic, an understanding of...

DOI: 10.1016/j.bmcl.2004.07.081 (opens in new tab) Full text (opens in new tab) Salvinorin a Drug metabolism Analytical methods Therapeutic potential

Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.

Life Sciences October 15, 2004 Feng Yan, Bryan L. Roth 68 citations

kappa-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A--a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human...

DOI: 10.1016/j.lfs.2004.07.008 (opens in new tab) Full text (opens in new tab) Salvinorin a Pharmacology Consciousness Kappa-opioid receptors

Localization of salvinorin A and related compounds in glandular trichomes of the psychoactive sage, Salvia divinorum.

Annals of botany June 2004 Daniel J Siebert

Salvia divinorum produces several closely related neoclerodane diterpenes. The most abundant of these, salvinorin A, is responsible for the psychoactive properties of the plant. To determine where these compounds occur in the plant, various organs, tissues and glandular secretions were chemically analysed. A microscopic survey of the S. divinorum plant was performed to examine the various types...

DOI: 10.1093/aob/mch089 (opens in new tab) Full text (opens in new tab)

The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys.

Psychopharmacology March 1, 2004 Eduardo R Butelman, Todd J Harris, Mary Jeanne Kreek 102 citations

Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would produce discriminative stimulus effects similar to those of a high efficacy kappa-agonist...

DOI: 10.1007/s00213-003-1638-0 (opens in new tab) Full text (opens in new tab) Salvinorin a Salvia divinorum Plant hallucinogen Psychoactive compound +21

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.

Journal of Pharmacology and Experimental Therapeutics March 1, 2004 Charles Chavkin, Sumit Sud, Wenzhen Jin et al. 212 citations

The diterpene salvinorin A from Salvia divinorum has recently been reported to be a high-affinity and selective kappa-opioid receptor agonist (Roth et al., 2002). Salvinorin A and selected derivatives were found to be potent and efficacious agonists in several measures of agonist activity using cloned human kappa-opioid receptors expressed in human embryonic kidney-293 cells. Thus, salvinorin...

DOI: 10.1124/jpet.103.059394 (opens in new tab) Full text (opens in new tab) Salvinorin a Salvia divinorum Natural compound Non-nitrogenous activator +13