Critical Analysis of the Total Synthesis of Salvinorin A
Alexander James Laurence Martin
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | Salvia divinorum |
| Key points | Argues that salvinorin A presents a unique avenue for psychopharmacological development, and that comparing two total syntheses of the trans-neoclerodane diterpenoid reveals their utility in synthesizing structural analogues for cognition and behavior research. |
Abstract
The past decade has been characterised by a resurgence in psychedelic research seeking to treat mental health issues, which claim over 700,000 lives each year. Salvinorin A, the main psychoactive substituent of Salvia divinorum, is a novel psychedelic distinct from those currently in clinical trials, presenting a unique avenue for further developments in psychopharmacology. In this essay, the biogenesis of salvinorin A will be discussed, followed by a critical comparison of two total syntheses of the trans-neoclerodane diterpenoid and their utility in synthesising structural analogues, affording useful tools in human cognition and behaviour research.
Comparable studies
Other theoretical and historical papers on salvia divinorum, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A. | 2008 | Theoretical or philosophical paper | |
| The claustrum's proposed role in consciousness is supported by the effect and target localization of Salvia divinorum. | 2014 | Theoretical or philosophical paper | |
| Total Synthesis of (-)-Salvinorin A. | 2016 | Theoretical or philosophical paper | |
| Scalable and modular synthesis enables pharmacological diversification of salvinorins | 2026 | Theoretical or philosophical paper | |
| Title: DMT, Salvinorin A, and Stress Regulation: An Exploratory Neuropharmacological Research Proposal | 2026 | Theoretical or philosophical paper |