Zenodo (CERN European Organization for Nuclear Research)
October 24, 2026
Odin Loch
preprint
Background. Safety is a property of a drug, in a population, in a context. Pharmaceutical MDMA (midomafetamine) given in a monitored psychotherapy trial, and material sold as ecstasy or MDMA outside that setting, are different exposures. This preprint compares those contexts side by side. It does not produce one pooled safety number. Methods. This is a rapid computational evidence synthesis:...
Zenodo (CERN European Organization for Nuclear Research)
October 21, 2026
Peter McGrath
preprint
Title: DMT, Salvinorin A, and Stress Regulation: An Exploratory Neuropharmacological Research Proposal Creator: Peter McGrath Affiliation: Appalachian State University Resource type: Publication — Working Paper Description: This independent undergraduate research proposal examines differences between the serotonergic mechanisms of N,N-DMT and the kappa-opioid receptor activity of salvinorin A,...
Brazilian Journal of Health Review
October 21, 2026
Pablo Henrique Lacerda Estaffe da Silva, Samela Demore Correa, Érico Torrieri
O uso terapêutico controlado de MDMA (3,4-metilenodioximetanfetamina) associado à psicoterapia tem ganhado destaque como abordagem para o transtorno de estresse pós-traumático (TEPT), especialmente em casos resistentes às terapias convencionais. Objetivo: sintetizar as evidências publicadas entre 2010 e 2025 sobre a eficácia, a segurança e os mecanismos de ação da terapia assistida por MDMA no...
Zenodo (CERN European Organization for Nuclear Research)
October 20, 2026
Lara Vervloet Carvalho, Sarah Isabela Magalhães Costa, Nathália Marques Santos et al.
preprint
As terapias assistidas por psicodélicos emergiram, na última década, como estratégia de investigação de destaque para transtornos psiquiátricos refratários às abordagens convencionais. Em ensaio de fase 2 controlado, dose única de 25 mg de psilocibina produziu redução média de 12,0 pontos na escala MADRS em pacientes com depressão resistente ao tratamento, superior à condição controle de 1 mg....
medRxiv
October 19, 2026
Joel Gelernter, Jack Hirsch, Cassie M. Overstreet et al.
preprint
Frequent nightmares affect roughly 2-6% of the population and may reflect underlying psychopathology, such as post-traumatic stress disorder (PTSD), or, when recurrent and distressing, be diagnosed as nightmare disorder (ND). The genetic basis of nightmares remains poorly understood. We performed a genome-wide association study (GWAS) meta-analysis of nightmare frequency (NF) across 207,243...
Journal of Happytalism and Fundamental Peace
October 14, 2026
Satinder Singh Rekhi, Saamdu Chetri, Luis Miguel Gallardo et al.
**Background.** Contemplative traditions have long associated water with stillness, concealment and renewal, and divers frequently describe underwater experience as meditative. This review asks whether immersion and submersion offer a distinctive context for mindfulness practice, and what the current evidence can and cannot support. **Methods.** A narrative review integrating epic and canonical...
Trials
October 14, 2026
Luca Pani, Fabio Tascedda
Abstract: Background: The registry record of psychedelic and related rapid-acting compounds is large, heterogeneous and laborious to synthesize by hand. We tested whether a large language model (LLM) with live access to the ClinicalTrials.gov application programming interface (API) could produce a timely, structured and reproducible characterization of this landscape. Methods: Cross-sectional...
Lviv University Herald Series Psychological sciences
October 12, 2026
Ruslan Hanushchak, Игорь Прись
У статті здійснено ретроспективний огляд розвитку психоделічної терапії та проаналізовано сучасний стан досліджень її ефективності у лікуванні психічних розладів. Простежено еволюцію використання психоделічних речовин – від традиційних духовних і лікувальних практик корінних народів через ранні клінічні дослідження середини ХХ століття до сучасного етапу, так званого «психоделічного ренесансу»....
JORMA International Journal of Health and Social Sciences
October 12, 2026
Michael Sersch
Current interest in the effectiveness of psychedelic-assisted recovery from trauma and other mental health conditions has been increasing. The Native American Church’s (NAC) use of the psychoactive plant peyote for over 100 years within sacred ritual has been a unique approach to religious expression and individual as well as collective healing, especially when addressing cultural trauma as...
PsyArXiv
October 9, 2026
Oleksandr Avramchuk, Olha Germanovych, Olha Ivanenko et al.
preprint
Background: Children living in conflict zones experience high levels of psychological distress. Schools can provide an accessible setting for support, yet evidence on the effectiveness of school-based interventions in active war contexts remains limited. Objectives: To evaluate children’s well-being and internal coping resources during the war in Ukraine and to examine the feasibility of a...