PTSD: all studies (page 46) - The Consciousness Library

A psychedelic win raises questions for PTSD therapy

Science May 21, 2021 Kelly Servick

MDMA tested along with talk therapy, but the ideal pairing has yet to be studied.

Military-related posttraumatic stress disorder and mindfulness meditation: A systematic review and meta-analysis

Chinese journal of traumatology = Zhonghua chuang shang za zhi May 18, 2021 Luna Sun, Jingwen Gu, Lijun Huang et al.

Purpose Posttraumatic stress disorder (PTSD) is a significant global mental health concern, especially in the military. This study aims to estimate the efficacy of mindfulness meditation in the treatment of military-related PTSD, by synthesizing evidences from randomized controlled trials. Methods Five electronic databases (Pubmed, EBSCO Medline, Embase, PsychINFO and Cochrane Library) were...

DOI: 10.1016/j.cjtee.2021.05.003 Full text

The Efficacy of MDMA (3,4-Methylenedioxymethamphetamine) for Post-traumatic Stress Disorder in Humans: A Systematic Review and Meta-Analysis

Cureus May 17, 2021 Sarah Tedesco, Ganeya Gajaram, Shahzad Chida et al. 31 citations

Background: 3,4-methylenedioxymethamphetamine (MDMA), known recreationally as "Molly" or "Ecstasy", is a triple monoamine reuptake inhibitor. MDMA specifically acts as a weak 5-HT1 and 5-HT2 receptor agonist, targeting 5-HT2A, 5-HT2B, and 5-HT2C receptors. Its potential use for therapeutic purposes with these pharmacological profiles remains a controversial subject. Studies have shown the...

DOI: 10.7759/cureus.15070 Full text MDMA Ecstasy Adverse effect Meta-analysis +3

Psychedelic‐assisted therapy considered ‘breakthrough’ treatment for PTSD

Mental Health Weekly May 17, 2021 Valerie A. Canady 1 citation

New research involving the use of psychedelic‐assisted therapy is showing promise and significant implications for patients with severe, chronic post‐traumatic stress disorder (PTSD) and could potentially move the needle further toward Food and Drug Administration (FDA) approval, say researchers from the Multidisciplinary Association for Psychedelic Studies (MAPS).

DOI: 10.1002/mhw.32791 Psychedelic therapy PTSD Treatment Trauma therapy Chronic PTSD Relief +14

Centrally acting anticholinergic drug trihexyphenidyl is highly effective in reducing nightmares associated with post-traumatic stress disorder.

Brain and Behavior May 14, 2021 Katsumasa Sogo, Masanobu Sogo, Yoshie Okawa

Introduction: Following a case study on scopolamine butyl bromide, an anticholinergic drug, we studied the effect of a central anticholinergic drug on post-traumatic stress disorder (PTSD)-related flashbacks and nightmares. Methods: We administered trihexyphenidyl (TP) to 34 patients with refractory PTSD-related nightmares and flashbacks (open-label trial [n = 22]; single-blind trial [n = 12]),...

DOI: 10.1002/brb3.2147 Full text PTSD Humans Trihexyphenidyl Cholinergic antagonists +7

Combining Ketamine and Internet-Based Cognitive Behavioral Therapy for the Treatment of Posttraumatic Stress Disorder: Protocol for a Randomized Controlled Trial

JMIR Research Protocols May 11, 2021 A. Philipp-Muller, Taras Reshetukha, Gustavo Vazquez et al.

Background Over one third of patients with posttraumatic stress disorder (PTSD) do not respond to current interventions. Ketamine presents a potential treatment option; however, its effects are temporary. Administering ketamine alongside psychotherapy is one potential means of prolonging its effects; however, only a few studies have investigated this treatment method to date, and none have...

DOI: 10.2196/30334 Full text

Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence

medRxiv Preprint Server April 10, 2021 Agnes Norbury, Sarah B. Rutter, Abigail B. Collins et al. 1 citation preprint

Promising initial data indicate that the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine may be beneficial in post-traumatic stress disorder (PTSD). Here, we explore the neural correlates of ketamine-related changes in PTSD symptoms, using a rich battery of functional imaging data (two emotion-processing tasks and one task-free scan), collected from a subset of participants...

DOI: 10.1101/2021.04.10.21255127 Full text PTSD Post-traumatic stress disorder Psychedelic therapy Mental health condition +13

Loving-Kindness Meditation vs Cognitive Processing Therapy for Posttraumatic Stress Disorder Among Veterans

JAMA Network Open April 1, 2021 David J. Kearney, Carol A. Malte, Meghan Storms et al.

Key Points Question Is group loving-kindness meditation noninferior to group cognitive processing therapy for treatment of posttraumatic stress disorder (PTSD) among veterans? Findings In this randomized clinical trial, 184 veterans with PTSD were assigned to group loving-kindness meditation or group cognitive processing therapy; the differences in the decrease from baseline to 6-month...

DOI: 10.1001/jamanetworkopen.2021.6604 Full text

Efficacy and safety results from the first pivotal phase 3 randomized controlled trial of mdma-assisted psychotherapy for treatment of severe chronic PTSD

European Psychiatry April 1, 2021 B. Van der Kolk

Introduction Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment options. Previous research has led to the designation of 3,4-methylenedioxymethamphetamine (MDMA) as a Breakthrough Therapy for treatment of post-traumatic stress disorder (PTSD) when administered as an adjunct to psychotherapy....

DOI: 10.1192/j.eurpsy.2021.391

Therapeutic interventions for PTSD – current evidence on the the role of psychedelics

European Psychiatry April 1, 2021 I. Figueiredo, Filipa Viegas, F. Ferreira et al. 2 citations

Introduction Post-traumatic stress disorder (PTSD) is often a chronic condition, despite the existence of evidence-based treatment options. Psychotherapy is the designated first line treatment for PTSD, although high rates of psychiatric and medical comorbidity are observed among patients who have undergone treatment. The psychoactive properties of psychedelics may be of particular interest...

DOI: 10.1192/j.eurpsy.2021.1209 Full text MDMA Psilocybin Psychotherapist Context archaeology +5