There is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective effects of LSD are mostly positive, negative subjective effects, including anxiety, may occur. The induction of overall positive acute subjective effects is desired in psychedelic-assisted therapy because positive acute experiences are associated with greater...
Treatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to achieve satisfactory treatment results. Although there are various definitions and grading models for TRD, common criteria for assessing TRD have still not been established. However, a common feature of any TRD model is the lack of response to at least...
Psychiatric disorders represent the largest cause of disability worldwide. Global interests in psychedelic substances as potentially therapeutic agents for psychiatric disorders has recently re-emerged. Here, we review progress in the development of psychedelic compounds that have potential therapeutic effects as well as the safety concerns. We include psilocybin, N,N-dimethyltryptamine (DMT),...
Psychedelic-assisted therapy has gained significant attention in recent years. However, there is a lack of empirical clarity on the role of psychosocial interventions (PIs) in clinical trials of psychedelic treatment due in part to deficiencies in reporting practices found in the existing literature. These PI include non-drug support or interventions provided by psychotherapists or facilitators...
The use of psychedelics for various purposes was common in different civilizations throughout human history and has been explored scientifically for more than a century. Although the applications of psychedelics show promise in the treatment of various psychiatric and neurological indications, as well as in facilitation of well-being and personal growth, several psychedelic-related risks and...
Cognition in extended brain-body music systems becomes especially agile during psychedelic experience, necessitating a sonic rhetoric emphasizing transformative agency. Rooted in the recursive listening spaces of dub, three forms of psychedelic electronica—ambient house, trip-hop and glitch—foster an echological sensibility unique to records made largely from the bits and pieces of other...
Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy- N,N -dimethyltryptamine (5-MeO-DMT)—a serotonergic psychedelic—as a novel, fast-acting therapeutic. Yet, few studies have directly...
Hausner originally doubted that she could be helped.But as he listened to a recording of Hana's third LSD session, he saw some hope."The most pronounced aspect of this session is her archetypal regression into the realm of antiquity and to the very beginnings of humanity," Hausner later wrote. 1 "Hana is beginning to formulate a new attitude toward death and eternity."Over the next six months,...
Dutch psychedelic history had its own characteristics. In psychiatry, LSD therapy was used for the management of the traumas of World War II; in Dutch society, overlapping groups of activists and psychedelics users were involved in a playful transformation of society into a “Magical Center”; and in economics, the Netherlands became a key player in the illegal production and distribution of LSD...
As of 2021, Israel is positioned at the forefront of a global revival of psychedelic research and culture.The small Middle Eastern country hosts clinical trials with psychedelics, generates multiple psychedelic start-ups, and hosts a pioneering psychedelic therapy training program.Popu lar interest in psychedelics is surging throughout the country as well, with multiple conferences, podcasts,...