Skilled interpersonal support and safety monitoring can enhance the therapeutic potential of psychedelic compounds and reduce the potential for harm. In the anticipation of legalized psychedelic care, and the recognition of ongoing psychedelic use across a variety of contexts, numerous training programs have been established to educate psychedelic facilitators in supporting individuals who take...
Background Recent years have seen renewed clinical interest in the therapeutic potential of classical psychedelics, such as psilocybin, LSD, DMT, and mescaline. While modern studies have focused on adult populations, adolescents under 18 are routinely excluded due to regulatory, legal, and ethical challenges. Although there exists observational data and historical studies from 1959 to 1974...
Psychedelic-Assisted Therapy (PAT) is a rapidly growing therapeutic approach that to date has rarely considered the nuanced needs of LGBTQA+ individuals. This study explores what LGBTQA+ individuals consider important for healthcare providers (HCPs) to consider when providing PAT. A global sample of LGBTQA+ individuals aged 18+ who had experience using a classic psychedelic compound at least...
I am requesting a correction to the article “Focused Bodywork as Facilitated Communication: Cautionary Perspectives on Touch in Psychedelic Therapy” by Neşe Devenot (2025). The article contains fac...
In his work on informed consent, Daniel Villiger (2025a) credibly argues that ignorance concerning the outcomes of transformative treatments need not undermine patient autonomy, while prohibitions ...
Acyloxymethyl (ACOM) derivatives of tryptamines such as the psychedelic drug psilocin and the anti-migraine drug sumatriptan bear potential as prodrugs. Previous synthetic approaches suffer from insufficient chemoselectivity between the desired functionalization of the phenolic (psilocin) or sulfonamide (sumatriptan) groups versus other reactive groups in the parent drugs. We report a novel...
Background: Psilocybin-assisted psychotherapy (PAP) is a promising treatment for various psychiatric disorders. However, the exact biological and psychological mechanisms of action of PAP remain to be determined. Examining predictors of PAP outcomes may help identify necessary processes for positive treatment outcomes. Mystical experiences are considered a key aspect of the subjective effects...
Psychedelics, derived from the Greek words "psyche" (soul) and "deloun" (revealing), are substances historically and currently considered "soul-revealing". Also termed hallucinogens due to their impact on sensory perception, they are further categorized into hallucinogens, such as lysergic acid diethylamide (LSD), psilocybin, and mescaline; entactogens or empathogens, such as...
Trauma-related disorders and substance use are disproportionately underdiagnosed and undertreated in individuals with High-Functioning Autism (Level 1 Autism Spectrum Disorder), particularly those in underserved or marginalized communities. Emerging evidence suggests that psychedelic-assisted therapies—including psilocybin, MDMA, and ketamine—offer promising outcomes in the treatment of...
PsychoactivesJune 25, 2025Guillermo Escobar-Cornejo, Fernando P. Cárdenas, Diego Torres et al.
Objective: To provide a state of the art on the use, role, and function of music during psychedelic-assisted therapy (PAT) with ayahuasca. Introduction: Ayahuasca is a medicinal brew with psychoactive qualities used by indigenous communities throughout the Amazon region, and music is deemed crucial during ayahuasca experiences. In PAT, music forms part of the set and setting, but it lacks...