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Wellcome Open Research

ISSN 2398-502X

4 papers in the library · 11 citations · publishing 2024-2025

Papers

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Clinical Psychedelic Therapy Research Involving Adolescents: Protocol for a Scoping Review of Intervention Studies

Wellcome Open Research July 8, 2025 Khaleel Rajwani, Melanie Almonte, F. Feroz et al. 2 citations

Background Recent years have seen renewed clinical interest in the therapeutic potential of classical psychedelics, such as psilocybin, LSD, DMT, and mescaline. While modern studies have focused on adult populations, adolescents under 18 are routinely excluded due to regulatory, legal, and ethical challenges. Although there exists observational data and historical studies from 1959 to 1974...

Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol

Wellcome Open Research April 22, 2025 Matthew Butler, Catherine Bird, Carolina Maggio et al. 3 citations

Background Functional neurological disorder (FND) is a common cause of neurological symptoms including seizures and movement disorders. It can be debilitating, is associated with high health and social care costs, and can have a poor prognosis. Functional magnetic resonance imaging (fMRI) has suggested FND is a multi-network disorder. Converging evidence suggests that other mechanisms including...

DOI: 10.12688/wellcomeopenres.22543.2 (opens in new tab) Psilocybin Magnetic resonance imaging Functional imaging Functional connectivity +2

Psychedelics as moral bioenhancers: Protocol for a scoping review of ethical arguments for and against.

Wellcome Open Research January 13, 2025 Samuel Streicher, Christopher Register, Xiu Lim et al. 2 citations

Background: Moral bioenhancement typically refers to the deliberate use of drugs or biotechnologies, potentially alongside other practices, to attempt to improve oneself morally. In addition to general concerns regarding moral self-bioenhancement, the possibility of using psychedelic substances for such purposes raises distinct ethical questions. As a first step in analysing these questions, we...

DOI: 10.12688/wellcomeopenres.23414.1 (opens in new tab) Full text (opens in new tab) Psychedelics Moral enhancement Bioethics Mental health

Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol.

Wellcome Open Research 2024 Matt Butler, Catherine Bird, Carolina Maggio et al. 4 citations

Functional neurological disorder (FND) is a common cause of neurological symptoms including seizures and movement disorders. It can be debilitating, is associated with high health and social care costs, and can have a poor prognosis. Functional magnetic resonance imaging (fMRI) has suggested FND is a multi-network disorder. Converging evidence suggests that other mechanisms including...

DOI: 10.12688/wellcomeopenres.22543.1 (opens in new tab) Full text (opens in new tab) Psilocybin Psychedelic medicine Neurological disorders Brain imaging +4