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OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...
OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...
September 18, 2025 Herlinda Flores Badillo
María Sabina became well known around the world for her great shamanic power and because people were intrigued by her and her relationship with hallucinogenic mushrooms, or niños santos (saint children), as she called them. The present chapter analyzes María Sabina’s prayers/chants – nijmi – in her mother tongue, Mazatec. Their anaphoric structure, commonly used by poets of this tradition, was...
bioRxiv Preprint Server September 18, 2025 C. Delgado-Sallent, S. A. Ahmed, A. Khawaja-Lopez et al. preprint
Psychedelics such as psilocybin and ketamine are gaining attention as rapid-acting treatments for psychiatric disorders, yet the mechanisms by which they alter cognition remain unclear. A key hypothesis—the REBUS model—proposes that psychedelics relax high-level priors, allowing bottom-up sensory information to exert greater influence over perception and behavior. Here, we test this model in...
Cureus September 17, 2025 Arya Kermanshah, Margo Stapleton, Christine M Mauriello et al. 1 citation
Ayahuasca, a brew containing N,N-dimethyltryptamine (DMT) with monoamine oxidase-inhibiting β-carbolines, has expanded from traditional use to global retreats. Reported adverse effects include vomiting, agitation, serotonin toxicity-like syndromes, and cardiovascular events. Rhabdomyolysis has been described with other classic hallucinogens (e.g., lysergic acid diethylamide and psilocybin),...
Clinical Toxicology September 15, 2025 Zhifan He, Rui Tang, Min Feng et al. 1 citation
Introduction Psychoactive Psilocybe spp. mushrooms pose significant public health risks. We report a cluster of Psilocybe keralensis poisonings in Chengdu, China, highlighting its unique clinical features and cardiovascular complications.Case Series Four patients ingested 16–90 g of wild mushrooms (misidentified as an edible species, but later molecularly confirmed as Psilocybe keralensis)....
Frontiers in Psychology September 15, 2025 Judith Hooper, Jarrod M. Ellingson, Kent E. Hutchison 2 citations
Introduction Aesthetic experiences under psychedelics are often described as vivid, emotionally powerful, and meaningful, yet they remain under-measured in psychometric research. This study aimed to refine and validate the Psychedelic Aesthetic Experience Questionnaire (PAEQ), a novel instrument designed to assess the aesthetic dimensions of acute psychedelic experiences. Methods A total of 365...
ACS Chemical Neuroscience September 13, 2025 Emma M. Bonniwell, Rana Alabdali, Joseph J. Hennessey et al. 3 citations
The serotonin 2C receptor (5-HT 2C ) is a G protein-coupled receptor implicated in multiple physiological and psychological processes and has been investigated as a therapeutic target for neuropsychiatric conditions such as obesity, drug abuse, and depression. With renewed interest in serotonergic psychedelics for treating depression, 5-HT 2C may contribute to psychedelic-induced therapeutic...
bioRxiv (Cold Spring Harbor Laboratory) September 12, 2025 Navid Shams Masjedi, Adeel Razi preprint
Abstract Decades of cross-species research highlight the claustrums extensive bidirectional connectivity with cortical and subcortical regions, implicating it in higher-order cognitive processes requiring synchronized brain states. Psychedelics may disrupt this synchrony by modulating claustro-cortical signaling, reflected by the dissolution of cortical network signatures. Using spectral...
Journal of Psychopharmacology September 12, 2025 Stephan Tap, Kelan Thomas, Tomáš Páleníček et al. 5 citations
Classic psychedelics are increasingly studied as potential treatments for different psychiatric disorders. Current research protocols often require patients to discontinue antidepressants (ADs) for at least 2 weeks before psychedelic administration to decrease the risk of serotonin syndrome and limit their effect on efficacy and the acute subjective effects of psychedelics. Moreover, the...