May 19, 2021
Evan Lewis-Healey, Ruben Laukkonen, Michiel van Elk
4 citations
preprint
Objective: Recent clinical trials have demonstrated that psilocybin may have strong antidepressant effects, and may be effective in the treatment of depressive disorders when embedded in a psychotherapeutic protocol (psilocybin-assisted psychotherapy; PAP). However, despite promising results, the mechanism(s) that may be responsible for the antidepressant effects of PAP remain contested. Within...
bioRxiv
May 17, 2021
preprint
LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory
Molecules
May 15, 2021
Henry Lowe, Ngeh J. Toyang, Blair Steele et al.
240 citations
The psychedelic effects of some plants and fungi have been known and deliberately exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal source of naturally occurring psychedelics. The mushroom extract, psilocybin has historically been used as a psychedelic agent for religious and spiritual ceremonies, as well as a therapeutic option for neuropsychiatric...
Brazilian Journal of Health Review
May 3, 2021
Fabiana Venancio Santana Silva, Alexandre Libanio Silva Reis, Amanda Prazeres Costa et al.
Dados da Organização Mundial de Saúde (OMS) informam que a depressão circunda entre as doenças mais incapacitantes do mundo, estimando-se que mais de 300 milhões de pessoas sofram com esta patologia. A psilocibina é um princípio ativo extraído do cogumelo do gênero Psilocybe de natureza química semelhante ao neurotransmissor serotonina (5- hidroxitriptamina) e a sua ação fisiológica em humanos...
Bipolar Disorders
May 2, 2021
H. Hendin, Andrew Penn
NT is a 21-year-old female identifying woman who came to the office of her outpatient psychiatric provider a month after a hospitalization for a brief psychotic episode, later diagnosed as mania, that she believes was triggered by consuming a substantial amount of psilocybe cubensis mushrooms that she had taken recreationally. While she has a positive family history (father and paternal...
Psychopharmacology
April 30, 2021
Michiel van Elk, George Fejer, Pascal Lempe et al.
53 citations
Abstract There is an increased societal trend to engage in microdosing, in which small sub-hallucinogenic amounts of psychedelics are consumed on a regular basis. Following subjective reports that microdosing enhances the experience of nature and art, in the present study we set out to study the effects of psilocybin microdosing on feelings of awe and art perception. In this preregistered...
Electronic Journal of General Medicine
April 27, 2021
Hisham Alshaikhli, Redhwan Ahmed Al-Naggar, Gwen Erlam
14 citations
Introduction: Psilocybin mushroom use is well documented in spiritual and religious ceremonies globally. This drug is now the most popular in Europe and the USA. \nObjective: The objective of this study is to explore the experiences and effects of psilocybin on patients with depression and anxiety. \nMethod: A qualitative study was conducted interviewing ten participants currently taking...
April 26, 2021
In patients with major depression, psilocybin was superior to a delayed-treatment control group with an effect size over 2 (relative effect sizes: 0.2 small, 0.5 medium, 1.0 large; antidepressants, on average, are 0.3). Who were these patients? Are they like yours?
Frontiers in Psychiatry
April 21, 2021
James Rucker, Allan H. Young
40 citations
Psilocybin has a long history of non-medical use and some seem to infer from this that it has therapeutic utility. Early phase clinical trials with psilocybin are encouraging, but suggest only that larger, multicentre trials are required. These are ongoing but will take many years to complete. Meanwhile, retreat centers offering paid experiences with psilocybin truffles have opened in some...
Brazilian Journal of Health Review
April 19, 2021
Giovanni Pereira Pio, Aline Moreira Vitorino, Naira Braga Aidar et al.
2 citations
Introdução: A depressão é um transtorno psiquiátrico caracterizado por episódios agudos ou recorrentes de humor deprimido e perda de interesse ou prazer, levando a prejuízos funcionais ao paciente. A psilocibina é uma droga psicodélica com propriedades alucinógenas e serotoninérgicas derivada de cogumelos do gênero Psilocybe. Estudos recentes demonstram potenciais efeitos terapêuticos dessa...