Psilocybin and psychedelic-assisted therapy: all studies (page 13)

Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.

Med March 8, 2024 Joshua D. Rosenblat, Shakila Meshkat, Zoe Doyle et al. 97 citations

Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations. Our aim was to determine the feasibility of PAP in a complex population, including high levels of treatment resistance in major depressive and bipolar disorder and patients with baseline suicidality and significant comorbidity....

DOI: 10.1016/j.medj.2024.01.005 Full text Major depressive disorder Treatment-resistant depression Psychedelic therapy Translation to patients +11

Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity.

Journal of Affective Disorders February 27, 2024 Debora Copa, David Erritzøe, Bruna Giribaldi et al. 31 citations

BackgroundPsilocybin is a serotonergic psychedelic drug under assessment as a potential therapy for treatment-resistant and major depression. Heterogeneous treatment responses raise interest in predicting the outcome from baseline data.MethodsA machine learning pipeline was implemented to investigate baseline resting-state functional connectivity measured with functional magnetic resonance...

DOI: 10.1016/j.jad.2024.02.089 Psychedelic therapy Psychedelic-assisted therapy Psilocybin therapy Psilocybin treatment +16

Development of a digital intervention for psychedelic preparation (DIPP).

Scientific Reports February 19, 2024 Rosalind McAlpine, Matthew D. Sacchet, Otto Simonsson et al. 13 citations

Psychedelic substances induce profound alterations in consciousness. Careful preparation is therefore essential to limit adverse reactions, enhance therapeutic benefits, and maintain user safety. This paper describes the development of a self-directed, digital intervention for psychedelic preparation. Drawing on elements from the UK Medical Research Council (MRC) framework for developing...

DOI: 10.1038/s41598-024-54642-4 Full text Psilocybin Psychedelic therapy Digital intervention Person-centred +6

Ketamine-assisted psychotherapy, psychedelic methodologies, and the impregnable value of the subjective—a new and evolving approach

Frontiers in Psychiatry February 1, 2024 Phil Wolfson, Gita Vaid 17 citations

Psychiatry is in a growth phase in which several psychedelic medicines have entered its arena with great promise. Of these, presently, ketamine is the only medicine that may be legally prescribed. We hypothesize that at subanesthetic doses, ketamine produces a unique spectrum of altered states, ranging from psychoactive to deep ego-dissolving experiences, that are intrinsic to ketamine’s...

DOI: 10.3389/fpsyt.2024.1209419 Ketamine Psilocybin Dissociative Consciousness +2

The impact of psychedelics on patients with alcohol use disorder: a systematic review with meta-analysis.

Current Medical Research and Opinion February 1, 2024 Dakota Sicignano, Adrían V. Hernández, Benjamin Schiff et al. 19 citations

Critique the available systematic review and de novo assessment of the role of psychedelics in the treatment of alcohol use disorder. A systematic literature search of PubMed was completed from 1960 to 9/9/2023. We pooled randomized controlled trials comparing psychedelics to control therapy for the treatment of alcohol use disorder. At the first recorded follow-up, LSD [n = 3, Odds Ratio (OR)...

DOI: 10.1080/03007995.2023.2296968 Full text LSD Alcohol use disorder Psilocybin Psychedelic therapy +5

Psilocybin-assisted psychotherapy for cancer patients

International Journal of Whole Person Care January 29, 2024 Houman Farzin

Despite significant advances in symptom management for patients affected by serious illness, physicians lack effective legal treatments for individuals suffering from demoralization, death anxiety, and existential distress. Psilocybin-assisted psychotherapy employs psilocybin-containing mushrooms or synthetic psilocybin grounded in indigenous traditions and within the context of a therapeutic...

DOI: 10.26443/ijwpc.v11i1.390 Psilocybin Psychotherapist Cancer

Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial.

BMC Psychiatry January 26, 2024 Laetitia Vanderijst, Felix Hever, Anne Buot et al. 11 citations

A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and preliminary clinical...

DOI: 10.1186/s12888-024-05502-y Full text Psychedelic therapy Psilocybin-assisted therapy Serotonergic psychedelics Clinical trials +3

Psilocybin for the treatment of posttraumatic stress disorder: A magic to treat a harmony of illusions?

Journal of Indira Gandhi Institute Of Medical Sciences 2024 Rakesh Khanna 1 citation

Abstract A review of the literature on posttraumatic stress disorder (PTSD) suggests it to be a complex disorder with many contributing factors. The concept of PTSD has continued to evolve over time. A diagnosis of PTSD may be hard to get right. Studies suggest a wide variation in its presentation and diagnostic stability. It is tempting to explore the possibility of using chemicals that could...

DOI: 10.4103/jigims.jigims_60_23 Psilocybin Psychedelic-assisted therapy Diagnostic uncertainties Posttraumatic stress disorder +1

IUPHAR-review: The integration of classic psychedelics into current substance use disorder treatment models.

Pharmacological Research 2024 David B. Yaden, Andrea P Berghella, Peter S. Hendricks et al. 12 citations

Substance use disorders (SUDs) have an enormous impact on public health. With classic psychedelic-assisted therapies showing initial promise in treating multiple SUDs, it is possible that these treatments will become legally available options for patients with SUDs in the future. This article highlights how classic psychedelic-assisted therapies might be integrated into current clinical...

DOI: 10.1016/j.phrs.2023.106998 Full text Psilocybin Substance use disorder Psychedelic therapy Medication assisted treatment +5

The Promise of Therapeutic Psilocybin: An Evaluation of the 134 Clinical Trials, 54 Potential Indications, and 0 Marketing Approvals on ClinicalTrials.gov.

Drug Design, Development and Therapy 2024 Sarah A Norring, Michael G Spigarelli 22 citations

Psilocybin, a tryptamine psychedelic, has been touted in the media both historically and recently as a potential game-changing mental health therapeutic. ClinicalTrials.gov has over one hundred and thirty psilocybin clinical trials listed covering the last twenty years. The single most important aspect of any therapeutic is to gain approval for marketing and thus enter the real-world phase of...

DOI: 10.2147/dddt.s443177 Full text Psilocin Psychedelic therapy FDA Approval Drug development +3