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Jack A Tuszynski

23 papers in the library · 46 citations · publishing 2002-2026

Papers

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Self-referential processing as the biological switch between classical and quantum functioning of the brain.

Frontiers in Human Neuroscience 2026 Josh Roeloffs, Jack A Tuszynski

Dual-process theory of the brain distinguishes fast, parallel, late-commitment cognition (System 1) from slow, sequential, early-commitment cognition (System 2), yet lacks a mechanistic explanation for how these modes operate or how the brain switches between them. Quantum cognition research demonstrates that human decision-making follows quantum probability models under low confidence and...

A Unified Holographic Framework for neural computation and consciousness: From lipid membranes to the Schumann resonance.

Biosystems 2026 Marco Cavaglià, Jack A Tuszynski

Understanding conscious experience requires looking beyond neuronal circuits alone. We propose that lipid membranes, vicinal water, and cerebrospinal fluid (CSF) form a coherent substrate capable of holographic encoding and coupling to endogenous/exogenous electromagnetic fields (EMF). In what follows: (i) we formulate four postulates (membrane as holographic plate; water as coherence medium;...

DOI: 10.1016/j.biosystems.2025.105669 (opens in new tab) Full text (opens in new tab) Holographic neural processing Lipid membrane computation Microtubule vibrations Quantum electrodynamics coherence +2

EMI model: A scale free biophysical framework for human consciousness, cognition and behaviour.

Biosystems January 2026 Tommaso Firaux, Jack A Tuszynski, Marco Cavaglià

Understanding consciousness, cognition, and behaviour requires an integrated framework capable of bridging neurobiology, physics, and information theory. In this paper, we propose the Energy-Mass-Information (EMI) framework as a novel paradigm to conceptualize mental phenomena as emergent properties of dynamic, field-based interactions. Rooted in, and direct expression of the Unified...

DOI: 10.1016/j.biosystems.2025.105674 (opens in new tab) Full text (opens in new tab) Cognitive dynamics Consciousness modeling Energy–mass–information framework Entropy and evolution +3

Quantum Brain Dynamics and Virtual Reality.

Biosystems August 1, 2024 Akihiro Nishiyama, Shigenori Tanaka, Jack A Tuszynski

In this paper we propose a control theory of manipulating holograms in Quantum Brain Dynamics (QBD) involving our subjective experiences, i.e. qualia. We begin with the Lagrangian density in QBD and extend our theory to a hierarchical model involving multiple layers covering the neocortex. We adopt reservoir computing approach or morphological computation to manipulate waveforms of holograms...

DOI: 10.1016/j.biosystems.2024.105259 (opens in new tab) Full text (opens in new tab) Control theory Holography Quantum brain dynamics Quantum field theory +1

Toward a holographic brain paradigm: a lipid-centric model of brain functioning.

Frontiers in Neuroscience 2023 Marco Cavaglià, Marco A Deriu, Jack A Tuszynski

Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that these dipole oscillations satisfy the weak Bose-Einstein condensate criteria of the Froehlich model of biological coherence. They can subsequently generate electromagnetic fields (EMFs) propagating in the inter-neuronal space. When...

DOI: 10.3389/fnins.2023.1302519 (opens in new tab) Full text (opens in new tab) Action potential Consciousness Electromagnetic field Holography +1

Alteration of Consciousness by Anaesthetics: A Multiscale Modulation from the Molecular to the Systems Level

Journal of Consciousness Studies June 1, 2022 Marco Cavaglià, E. A. Zizzi, S. Dombrowski et al.

General anaesthesia has been used in medical practice since the mid-nineteenth century, but its pharmacological mechanism of action is still not entirely clear. In a top-down approach, investigations probe smaller and smaller scales to shed light on how anaesthetics disrupt or alter neural activity, ultimately resulting in loss of consciousness. In the past few decades, advances in neuroscience...

From Quantum Biology Towards Quantum Consciousness

May 24, 2021 Jack A Tuszynski

This chapter presents a historical overview of the development and application of quantum physics methodology to various fields of science beyond physics, especially biology and consciousness. In recent years, individual biological phenomena such as photosynthesis and bird navigation have been experimentally and theoretically analysed using quantum methods, building conceptual foundations for...

From quantum chemistry to quantum biology: a path toward consciousness.

Journal of Integrative Neuroscience December 30, 2020 Jack A Tuszynski

This paper presents a historical overview of quantum physics methodology's development and application to various science fields beyond physics, especially biology and consciousness. Following a successful interpretation of several early 20t⁢h century experiments, quantum physics gradually provided a conceptual framework for molecular bonds via quantum chemistry. In recent years individual...

DOI: 10.31083/j.jin.2020.04.393 (opens in new tab) Full text (opens in new tab) Quantum physics Consciousness Quantum biology Quantum metabolism

Spontaneous potentiality as formative cause of thermo-quantum consciousness

Journal of Integrative Neuroscience March 23, 2020 Roman R. Poznanski, Lleuvelyn A Cacha, A. Z. A. Latif et al.

A macro-quantum model is developed to describe spontaneous processes in terms of computable equations. The resultant macro-quantum wave equation (Schr?dinger-type equation) is solved via a Madelung transformation to yield a complex-valued solution whose real part gives the macro-quantum potential energy. We show that the mechanism responsible for spontaneous phase differences is a pilot-wave...

Theorizing how the brain encodes consciousness based on negentropic entanglement.

Journal of Integrative Neuroscience March 30, 2019 Roman R. Poznanski, Lleuvelyn A Cacha, A Z A Latif et al.

The physicality of subjectivity is explained through a theoretical conceptualization of guidance waves informing meaning in negentropically entangled non-electrolytic brain regions. Subjectivity manifests its influence at the microscopic scale of matter originating from de Broglie 'hidden' thermodynamics as action of guidance waves. The preconscious experienceability of subjectivity is...

DOI: 10.31083/j.jin.2019.01.105 (opens in new tab) Full text (opens in new tab) Consciousness code Electron clouds Guidance waves Macro-quantum wave equation +4

Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system.

Biosystems November 1, 2018 Nadezhda Barvitenko, Alfons Lawen, Muhammad Aslam et al.

Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. A theoretical study of the role of the complex composed of the...

DOI: 10.1016/j.biosystems.2018.08.007 (opens in new tab) Full text (opens in new tab) Centrosome Memory Microtubule Signal transduction +2

A dialogue on the issue of the “quantum brain” between consciousness and unconsciousness

Journal of Integrative Neuroscience November 7, 2017 Massimo Cocchi, Fabio Gabrielli, Lucio Tonello et al. 2 citations

In this paper, we present some diverse points of view on the issue of the quantum brain.The paper is structured in the form of opening statements by each of the co-authors followed by comments and critique presented by the other co-authors. The main focus of the discussion is on the interplay between the state of being alive and consciousness, both of which possess characteristics of quantum...

Are there optical communication channels in the brain?

arXiv Preprint Archive August 23, 2017 Parisa Zarkeshian, Sourabh Kumar, Jack A Tuszynski et al. preprint

Despite great progress in neuroscience, there are still fundamental unanswered questions about the brain, including the origin of subjective experience and consciousness. Some answers might rely on new physical mechanisms. Given that biophotons have been discovered in the brain, it is interesting to explore if neurons use photonic communication in addition to the well-studied electro-chemical...

Full text (opens in new tab) Physics.bio-ph Physics.optics Q-bio.nc Quant-ph

Stream of consciousness: Quantum and biochemical assumptions regarding psychopathology.

Medical Hypotheses April 1, 2017 Lucio Tonello, Massimo Cocchi, Fabio Gabrielli et al.

The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousness seem to offer a profound change to the current approaches. Unfortunately...

Document of Trapani on animal consciousness and quantum brain function: A hypothesis

Journal of Integrative Neuroscience 2017 Massimo Cocchi, Gustav Bernroider, M. Rasenick et al.

Massimo Cocchi a,∗, G. Bernroider b, Mark Rasenick c, Lucio Tonello a, Fabio Gabrielli d and Jack A. Tuszynski e a Department of Veterinary Medical Sciences, University of Bologna, Italy b Neurosignaling Unit, University of Salzburg, Austria c Department of Physiology and Biophysics, College of Medicine, University of Illinois, Jesse Brown VAMC, Chicago, IL, USA d Theological Faculty of...

On the possible quantum role of serotonin in consciousness.

Journal of Integrative Neuroscience September 1, 2015 Lucio Tonello, Massimo Cocchi, Fabio Gabrielli et al.

Cell membrane's fatty acids (FAs) have been carefully investigated in neurons and platelets in order to study a possible connection to psychopathologies. An important link between the FA distribution and membrane dynamics appears to emerge with the cytoskeleton dynamics. Microtubules (MTs) in particular have been implicated in some recent quantum consciousness models and analyses. The recently...

Quantum effects in the understanding of consciousness.

Journal of Integrative Neuroscience June 1, 2014 Stuart Hameroff, Travis J A Craddock, Jack A Tuszynski

This paper presents a historical perspective on the development and application of quantum physics methodology beyond physics, especially in biology and in the area of consciousness studies. Quantum physics provides a conceptual framework for the structural aspects of biological systems and processes via quantum chemistry. In recent years individual biological phenomena such as photosynthesis...

DOI: 10.1142/s0219635214400093 (opens in new tab) Full text (opens in new tab) Quantum coherence Consciousness Microtubules Quantum biology

Keeping time: could quantum beating in microtubules be the basis for the neural synchrony related to consciousness?

Journal of Integrative Neuroscience June 2014 Travis J A Craddock, Avner Priel, Jack A Tuszynski

This paper discusses the possibility of quantum coherent oscillations playing a role in neuronal signaling. Consciousness correlates strongly with coherent neural oscillations, however the mechanisms by which neurons synchronize are not fully elucidated. Recent experimental evidence of quantum beats in light-harvesting complexes of plants (LHCII) and bacteria provided a stimulus for seeking...

DOI: 10.1142/s0219635214400019 (opens in new tab) Full text (opens in new tab) Consciousness Microtubules Neural synchrony Quantum biology +1

Near death experiences: a multidisciplinary hypothesis

Frontiers in Human Neuroscience 2013 István Bókkon, Birendra N. Mallick, Jack A Tuszynski 42 citations

Recently, we proposed a novel biophysical concept regarding on the appearance of brilliant lights during near death experiences (NDEs) (Bókkon and Salari, 2012). Specifically, perceiving brilliant light in NDEs has been proposed to arise due to the reperfusion that produces unregulated overproduction of free radicals and energetically excited molecules that can generate a transient enhancement...

A critical assessment of the information processing capabilities of neuronal microtubules using coherent excitations.

Journal of Biological Physics January 2010 Travis John Adrian Craddock, Jack A Tuszynski

Evidence for signaling, communication, and conductivity in microtubules (MTs) has been shown through both direct and indirect means, and theoretical models predict their potential use in both classical and quantum information processing in neurons. The notion of quantum information processing within neurons has been implicated in the phenomena of consciousness, although controversies have...

How Can the Visual Quantum Information be Transferred to The Brain Intact, Collapsing There and Causing Consciousness?

NeuroQuantology November 24, 2009 Majid Rahnama, Vahid Salari, Jack A Tuszynski 2 citations

The main problem which this paper tries to address is whether collapse of the wave function describing the state of a quantum mechanical system occurs, or, rather can occur in the brain of the observer or not. One of the first (relatively) detailed “collapse models” following the original abstract suggestion by von Neumann that collapse occurs in the brain of the observer and is related to...

On the Theoretical Possibility of Quantum Visual Information Transfer to the Human Brain

arXiv Preprint Archive August 29, 2008 Vahid Salari, M. Rahnama, Jack A Tuszynski preprint

The feasibility of wave function collapse in the human brain has been the subject of vigorous scientific debates since the advent of quantum theory. Scientists like Von Neumann, London, Bauer and Wigner (initially) believed that wave function collapse occurs in the brain or is caused by the mind of the observer. It is a legitimate question to ask how human brain can receive subtle external...

Full text (opens in new tab) Quant-ph Q-bio.nc Quantum biology Quantum biophysics +14

Conduction pathways in microtubules, biological quantum computation, and consciousness.

Biosystems 2002 Stuart Hameroff, Alex Nip, Mitchell Porter et al.

Technological computation is entering the quantum realm, focusing attention on biomolecular information processing systems such as proteins, as presaged by the work of Michael Conrad. Protein conformational dynamics and pharmacological evidence suggest that protein conformational states-fundamental information units ('bits') in biological systems-are governed by quantum events, and are thus...

DOI: 10.1016/s0303-2647(01)00183-6 (opens in new tab) Microtubules Humans Tubulin Anesthesia +9