Psychiatria PolskaApril 30, 2026Bronisław Gębik, Katarzyna Bliźniewska-Kowalska, Piotr Gałecki
Od 2000 roku ketamina i jej enancjomery są badane pod kątem swojego działania przeciwdepresyjnego. W niniejszej pracy zostanie krótko podsumowana droga ketaminy od anestetyku do leku przeciwdepresyjnego. W tekście przedstawione zostaną najważniejsze mechanizmy jej działania a także działania jej metabolitów. Praca ta ma na celu opisać rolę konkretnych grup receptorów w aktywacji istotnych...
This article explores the evolution of human identity in an era marked by neuroscience, digitalization and cyborg embodiment. Starting at the most basic neuroscientific model of how memory, perception and empathy are innate to consciousness, it retraces the many steps that create ‘the self’. It contends that identity is not a biological fixed essence but rather a process, moulded by...
Abstract This paper outlines the biological foundations of the Process-Contact Theory of the Psyche (PCTP). Its task is not to reduce psychic processes to neurobiological mechanisms but to establish in which physiological and molecular mechanisms the theory's ontological premises are realized, and with what degree of rigor such relations can be asserted. The argument is organized around three...
The treatment of treatment-resistant depression (TRD) remains a clinical challenge. Pharmacologically, several augmentation options exist. The aim of this study was to present a mechanistically informed and clinically oriented decision-making framework for the established strategies of lithium, quetiapine, and esketamine. We conducted a narrative, non-systematic review, performing a targeted...
Psychedelic drugs are serotonergic hallucinogens that can be divided into two types: naturally occurring (psilocybin, psilocin, and N,N-dimethyltryptamine) and synthetic (LSD, MDMA, 2,5-dimethoxy-4-iodoamphetamine, and ketamine). Psychedelics generally work on 5-hydroxytryptamine receptors and might be useful in cognitive enhancement, brain connectivity, neuroplasticity, and neuronal...
Long-term memory exhibits a remarkable problem: it is extraordinarily stable over decades, yet it supports rapid, flexible cognition, logic, and conscious awareness. Classical neuroscience has largely attributed memory to synaptic plasticity and networklevel dynamics; however, these mechanisms alone do not adequately explain the molecular durability of memory traces in the face of continuous...
The integration of psychedelics and music in therapeutic settings is gaining recognition for its potential to enhance mental health outcomes. This review synthesizes current evidence on the neurobiological mechanisms underlying this synergy, focusing on receptor-level pathways (e.g., 5-HT2A receptor agonism, BDNF-TrkB signaling) and neural circuit dynamics (e.g., default mode network...
Methamphetamine (MA) use disorder is associated with widespread disruption of large-scale brain networks involved in cognitive control, attention, and salience processing. Resting-state functional MRI (rs-fMRI) provides a means to characterize these alterations; however, little is known about the capacity for functional network reorganization following targeted intervention. The purpose of this...
РЕЗЮМЕ. Кетамін, відомий понад 60 років як дисоціативний анестетик, демонструє унікальний мультимодальний фармакологічний профіль, що виходить за межі класичного NMDA-антагонізму. Ця комплексна дія стала основою для його клінічної еволюції та «перевідкриття» у нових терапевтичних нішах, зокрема у психіатрії. Мета – систематизувати та проаналізувати наукові дані щодо клінічної еволюції кетаміну:...
The classic psychedelic psilocybin elicits long-lasting neural plasticity and behavioral effects, but prior studies largely examined stress-naive animals. Using longitudinal imaging, we show that psilocybin increases dendritic spine density in frontal cortical neurons and facilitates fear extinction after chronic restraint stress, demonstrating psilocybin's effects in a translationally relevant...